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Moscow University Chemistry Bulletin

, Volume 73, Issue 6, pp 272–279 | Cite as

Determination of Cotinine in Urine and Wastewaters by High Performance Liquid Chromatography Coupled with Tandem Mass-Spectrometric Detection

  • M. JangEmail author
  • A. V. Pirogov
  • A. A. Maksimova
  • V. I. Dobrovolskiy
  • A. A. Stakheev
  • J. V. Abramova
  • A. A. Priadka
  • A. P. Jaricov
  • A. E. Nosyrev
  • V. V. Rozhanets
  • O. A. Shpigun
Article

Abstract

A technique of extracting cotinine in urine and wastewaters, followed by its quantitative determination, using high performance liquid chromatography combined with tandem mass-spectrometric detection is presented. The method is characterized by low detection limits and high levels of efficiency and sensitivity. The optimal conditions for the solid-phase extraction of cotinine from urine and wastewaters are found. This technique makes it possible to reliably estimate the content of cotinine in the urine of active and passive smokers and in wastewaters.

Keywords

cotinine high performance liquid chromatography mass-spectrometry wastewaters urine solid-phase extraction 

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References

  1. 1.
    Rozhanets, V.V., Vopr. Narkol., 2016, nos. 7–8, p. 54.Google Scholar
  2. 2.
    Pianezza, M.L., Sellers, E.M., and Tyndale, R.F., Nature, 1998, vol. 393, no. 6687, p. 750.CrossRefGoogle Scholar
  3. 3.
    Abdallaha, I.A., Hammell, D.C., Stinchcomb, A.L., and Hassan, H.E., J. Chromatogr. B: Anal. Technol. Biomed. Life Sci., 2016, vol. 1020, p. 67.CrossRefGoogle Scholar
  4. 4.
    Medana, C., Aigotti, R., Sala, C., Dal Bello, F., Santoro, V., Gastaldi, D., and Baiocchi, C., Spectroscopy, 2016, vol. 14, no. 2, p. 20.Google Scholar
  5. 5.
    Sommerfeld, K., Łukasik-Głębocka, M., Kulza, M., Drużdż, A., Panieński, P., and Zielińska-Psuja, B., Forensic Sci. Int., 2016, vol. 262, p. e15.Google Scholar

Copyright information

© Allerton Press, Inc. 2018

Authors and Affiliations

  • M. Jang
    • 1
    Email author
  • A. V. Pirogov
    • 1
  • A. A. Maksimova
    • 1
  • V. I. Dobrovolskiy
    • 2
  • A. A. Stakheev
    • 2
  • J. V. Abramova
    • 2
  • A. A. Priadka
    • 2
  • A. P. Jaricov
    • 3
  • A. E. Nosyrev
    • 4
  • V. V. Rozhanets
    • 3
  • O. A. Shpigun
    • 1
  1. 1.Department of ChemistryMoscow State UniversityMoscowRussia
  2. 2.All-Russia Research Institute of Physicotechnical and Radio Engineering MeasurementsMoscowRussia
  3. 3.Research Institute of Drug Abuse, Branch of Serbsky Federal Medical Research Center for Psychiatry and Drug AbuseMinistry of Health of RussiaMoscowRussia
  4. 4.National Research Center of Pharmacy, Sechenov First Moscow State Medical UniversityMinistry of Health of RussiaMoscowRussia

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