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Orofacial clefts and infections during pregnancy

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Abstract

Orofacial clefts (OFCs) are common congenital malformations of the lip, palate, or both caused by complex genetic and environmental factors. Specific antibodies against viruses influenza, rubella, cytomegalovirus, Epstein-Barr, parotitis and hepatitis B were investigated serologically in children with orofacial clefts and in their mothers. The results were compared with those obtained in control children and their mothers. Evaluation of the results and their statistical processing supports the assumption that infection during pregnancy may have occurred in the series studied induced by viruses of influenza, rubella, cytomegalovirus and possibly also by the Epstein-Barr virus. No association with the viruses of hepatitis B and parotitis was established.

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Abbreviations

HIT:

Hemagglutination inhibition test

KFR:

Complement fixation test

NIR:

Indirect immunofluorescence assay

ELISA:

Enzyme-linked immunosorbent assay

RIA:

Radioimmuno assay.4

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Acknowledgments

This work was supported by the and Grant VEGA 2/0129/15. Authors would like to thank to team of Center for Orofacial Clefts in Hospital Ružinov Bratislava.

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Authors and Affiliations

  1. Department of Plastic Surgery, Faculty of Medicine, Comenius University, Hospital Ružinov, Ružinovská 6, 82606, Bratislava, Slovakia

    Agáta Molnárová, Drahomír Palenčár & Dagmar Fekiačová

  2. Department of Gynecology, Faculty of Medicine, Comenius University, Hospital Ružinov, Ružinovská 6, Bratislava, 82606, Slovakia

    Eva Bieliková

  3. Public Health Authority of the Slovak Republic, Trnavská cesta 52, Bratislava, 82645, Slovakia

    Eva Tichá

  4. Institute of Experimental Pharmacology and Toxicology, Centre of Experimental Medicine of the Slovak Academy of Sciences, Dúbravská cesta 9, Bratislava, 84104, Slovakia

    Eduard Ujházy

Authors
  1. Agáta Molnárová
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  2. Drahomír Palenčár
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  3. Dagmar Fekiačová
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  4. Eva Bieliková
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  5. Eva Tichá
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  6. Eduard Ujházy
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Correspondence to Eduard Ujházy.

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Molnárová, A., Palenčár, D., Fekiačová, D. et al. Orofacial clefts and infections during pregnancy. Biologia 73, 629–635 (2018). https://doi.org/10.2478/s11756-018-0065-y

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