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“Green synthesis” of benzothiazepine library of indeno analogues and their in vitro antimicrobial activity

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Abstract

A novel series of indeno-benzothiazepine derivatives was synthesised via a “green” route. Synthesis of these compounds involves the treatment of dinucleophiles such as 2-aminobenzenethiols with α,β-unsaturated ketones in poly(oxyethylene) (poly(ethylene glycol), PEG-400) catalysed by acetic acid. The synthone α,β-unsaturated ketones were obtained by Claisen-Schmidt condensation of indan-1-one with substituted pyrazole-2-carbaldehydes prompted by bleaching earth (pH 12.5) as catalyst and PEG-400 as “green” reaction solvent. Screening of all the synthesised compounds for antimicrobial activity revealed that most of these compounds exhibited moderate to significant antimicrobial activity.

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Authors and Affiliations

  1. School of Chemical Sciences, Swami Ramanand Teerth Marathwada University, Nanded, MS, India, 431606

    Ashok P. Acharya, Snehalkumar D. Patil, Shrikant V. Hese, Omprakash S. Yemul & Bhaskar S. Dawane

  2. Maharashtra Udayagiri Mahavidyalaya, Udgir, MS, India, 413517

    Rahul D. Kamble, Sudhakar G. Patil & Shivshankar N. Halale

Authors
  1. Ashok P. Acharya
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  2. Rahul D. Kamble
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  3. Snehalkumar D. Patil
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  4. Shrikant V. Hese
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  5. Omprakash S. Yemul
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  6. Sudhakar G. Patil
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  7. Shivshankar N. Halale
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  8. Bhaskar S. Dawane
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Correspondence to Bhaskar S. Dawane.

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Acharya, A.P., Kamble, R.D., Patil, S.D. et al. “Green synthesis” of benzothiazepine library of indeno analogues and their in vitro antimicrobial activity. Chem. Pap. 68, 719–724 (2014). https://doi.org/10.2478/s11696-013-0496-4

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  • DOI: https://doi.org/10.2478/s11696-013-0496-4

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