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Facile synthesis of 3-substituted quinazoline-2,4-dione and 2,3-di-substituted quinazolinone derivatives

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Abstract

3-Substituted quinazoline-2,4(1H,3H)-dione and 2,3-di-substituted quinazolineone derivatives attract considerable interest due to their pharmacological properties. In this paper, we report the synthesis of N-substituted-3-nitrophthalimide derivatives II–III, the reactions of phthalimide III with amines, hydrazines, and amino acid derivatives to synthesise a small library of 3-substituted-5-nitroquinazoline-2,4(1H,3H)-diones IV–XIV and 2,3-di-substituted-6-nitro-quinazolineones XVIII–XIX.

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Authors and Affiliations

  1. College of Sciences & Humanity studies, Salman Bin Abdalaziz University, P. O. Box 83, Alkharj, 11942, Saudi Arabia

    Mahmoud Farouk

  2. Centre of Excellence in Biotechnology Research, King Saud University, P. O. Box 2460, Riyadh, 11451, Saudi Arabia

    Salman A. Alrokayan & Ahamad Imran

  3. Research Chair of Targeting and Treatment of Cancer Using Nanoparticles, King Abdullah Institute for Nanotechnology, King Saud University, P. O. Box 2454, Riyadh, 11451, Saudi Arabia

    Khalid M. Abu-Salah

  4. Chemistry Department, College of Science, King Saud University, P. O. Box 2455, Riyadh, 11451, Saudi Arabia

    Mohamed Ghazzali & Khalid A. Al-Farhan

  5. Chemistry Department, Faculty of Science, South Valley University, Qena, 83523, Egypt

    Salem El-Gohary & Mamdouh Adly

Authors
  1. Mahmoud Farouk
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  2. Salman A. Alrokayan
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  3. Ahamad Imran
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  4. Khalid M. Abu-Salah
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  5. Mohamed Ghazzali
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  6. Khalid A. Al-Farhan
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  7. Salem El-Gohary
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  8. Mamdouh Adly
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Correspondence to Mahmoud Farouk.

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Farouk, M., Alrokayan, S.A., Imran, A. et al. Facile synthesis of 3-substituted quinazoline-2,4-dione and 2,3-di-substituted quinazolinone derivatives. Chem. Pap. 67, 229–235 (2013). https://doi.org/10.2478/s11696-012-0266-8

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  • DOI: https://doi.org/10.2478/s11696-012-0266-8

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