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Chemical Papers

, Volume 67, Issue 2, pp 245–248 | Cite as

A new phenanthroindolizidine alkaloid from Tylophora indica

  • Mini DhimanEmail author
  • Amit Khanna
  • Sreedharannair L. Manju
Short Communication
  • 232 Downloads

Abstract

A new phenanthroindolizidine alkaloid, 3-O-demethyl tylophorinidine (VI), was isolated from the aerial (leaves and stem) parts of Tylophora indica and characterized using different spectral techniques. Gel chromatography and reverse phase preparative HPLC were used for sample purification. The new alkaloid, VI, was screened for anticancer activity against a panel of different cancer cell lines and it showed significant anticancer activity with IC50 value in the range of 0.89–1.40 μM.

Keywords

Tylophora indica asclepiadaceae phenanthroindolizidine alkaloids anticancer 

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Copyright information

© Institute of Chemistry, Slovak Academy of Sciences 2012

Authors and Affiliations

  • Mini Dhiman
    • 1
    Email author
  • Amit Khanna
    • 2
  • Sreedharannair L. Manju
    • 3
  1. 1.Special Projects Analytical ChemistryMumbaiIndia
  2. 2.High Throughput Screening and BiotechnologyDivision Nirlon ComplexMumbaiIndia
  3. 3.Organic Chemistry DivisionVellore Institute of Technology UniversityVelloreIndia

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