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Induction of Cryptococcus laurentii α-galactosidase

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An Errata to this article was published on 12 July 2012

Abstract

The surface activity of Cryptococcus laurentii α-galactosidase can be significantly (up to 80 times) influenced by a carbon source present in a cultivation medium. Induction of this enzyme is stimulated by the presence of saccharides containing bound galactose. The highest activity observed when the cells grew in a lactose medium was probably a consequence of the absence of cleavage products serving as repressors (glucose). This idea is supported by the poor growth of cells in the medium with lactose as the carbon source. The induction of surface α-galactosidase was accompanied by increased activities in cytosole. The membrane fraction also contained this enzyme, but the influence of the carbon source was not proportional. The induction of α-galactosidase may play an important role in galactose metabolism of the genus Cryptococcus with a direct influence on the virulence of these capsular yeasts.

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Authors and Affiliations

  1. Institute of Chemistry, Slovak Academy of Sciences, Dúbravská cesta 9, SK-845 38, Bratislava, Slovakia

    Csilla Mészárosová, Nadežda Kolarova, Renáta Vadkertiová & Eva Stratilová

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  1. Csilla Mészárosová
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  2. Nadežda Kolarova
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  3. Renáta Vadkertiová
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  4. Eva Stratilová
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Correspondence to Eva Stratilová.

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Mészárosová, C., Kolarova, N., Vadkertiová, R. et al. Induction of Cryptococcus laurentii α-galactosidase. Chem. Pap. 66, 806–813 (2012). https://doi.org/10.2478/s11696-012-0170-2

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