Abstract
Hybrid processes have received increased attention in the field of chemical and biochemical engineering because of their ability to overcome certain obstacles related to thermodynamics of the separation task to be carried out. Usually, in a hybrid process two processes are coupled; either reaction with separation or two different separation processes. In the design of such hybrid systems, the performance of each constituent element has to be taken into account, while their optimisation must account for their interdependency. In this paper, the methodology presented by Mitkowski et al. (2009a) is applied to design and analyse a hybrid process scheme for the synthesis of ethyl lactate. Generated hybrid process schemes have been validated through computer-aided simulations.
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Adams, T. A., II, & Seider, W. D. (2008). Semicontinuous distillation for ethyl lactate production. AIChE Journal, 54, 2539–2552. DOI: 10.1002/aic.11585.
Benedict, D. J., Parulekar, S. J., & Tsai, S. P. (2006). Pervaporation-assisted esterification of lactic and succinic acids with downstream ester recovery. Journal of Membrane Science, 281, 435–445. DOI: 10.1016/j.memsci.2006.04.012.
Benedict, D. J., Parulekar, S. J., & Tsai, S.-P. (2003). Esterification of lactic acid and ethanol with/without pervaporation. Industrial & Engineering Chemistry Research, 42, 2282–2291. DOI: 10.1021/ie020850i.
Blahušiak, M., Schlosser, Š., & Marták, J. (2010). Simulation of a hybrid fermentation-separation process for production of butyric acid. Chemical Papers, 64, 213–222. DOI: 10.2478/s11696-009-0114-7.
Buchaly, C., Kreis, P., & Górak, A. (2007). Hybrid separation processes-Combination of reactive distillation with membrane separation. Chemical Engineering and Processing, 46, 790–799. DOI: 10.1016/j.cep.2007.05.023.
CAPEC (Computer Aided Process Engineering Center) (2008). Integrated computer aided system (ICAS) (Manual delivered with ICAS software). Lyngby, Denmark: Technical University of Denmark.
CAPEC (Computer Aided Process Engineering Center) (2002). ICAS documentations. Lyngby, Denmark: Technical University of Denmark. (CAPEC Internal Report, PEC02-14).
Delgado, P., Sanz, M. T., & Beltrán, S. (2007a). Isobaric vapour-liquid equilibria for the quaternary reactive system: Ethanol + water + ethyl lactate + lactic acid at 101.33 kPa. Fluid Phase Equilibria, 255, 17–23. DOI: 10.1016/j.fluid.2007.03.022.
Delgado, P., Sanz, M. T., & Beltrán, S. (2007b). Kinetic study for esterification of lactic acid with ethanol and hydrolysis of ethyl lactate using an ion-exchange resin catalyst. Chemical Engineering Journal, 126, 111–118. DOI: 10.1016/j.cej.2006.09.004.
Engin, A., Haluk, H., & Gurkan, K. (2003). Production of lactic acid esters catalyzed by heteropoly acid supported over ion-exchange resins. Green Chemistry, 5, 460–466. DOI: 10.1039/b303327a.
Gani, R., Hytoft, G., Jaksland, C., & Jensen, A. K. (1997). An integrated computer aided system for integrated design of chemical processes. Computers & Chemical Engineering, 21, 1135–1146. DOI: 10.1016/S0098-1354(96)00324-9.
Gani, R., Jiménez-González, C., & Constable, D. J. C. (2005). Method for selection of solvents for promotion of organic reactions. Computers & Chemical Engineering, 29, 1661–1676. DOI: 10.1016/j.compchemeng.2005.02.021.
Gani, R., & O’Connell, J. P. (1989). A knowledge based system for the selection of thermodynamic models. Computers & Chemical Engineering, 13, 397–404. DOI: 10.1016/0098-1354(89)85019-7.
Koszorz, Z., Nemestothy, N., Ziobrowski, Z., Belafi-Bako, K., & Krupiczka, R. (2004). Influence of pervaporation process parameters on enzymatic catalyst deactivation. Desalination, 162, 307–313. DOI: 10.1016/S0011-9164(04)00064-5.
Lipnizki, F., Field, R. W., & Ten, P.-K, (1999). Pervaporation-based hybrid process: a review of process design, applications and economics. Journal of Membrane Science, 153, 183–210. DOI: 10.1016/S0376-7388(98)00253-1.
Matouq, M., Tagawa, T., & Goto, S. (1994). Combined process for production of methyl tert-buthyl ether from tert-buthyl alcohol and methanol. Journal of Chemical Engineering of Japan, 27, 302–306. DOI: 10.1252/jcej.27.302.
Mihaľ, M., Švandovǎ, Z., & Markoš, J. (2010). Steady state and dynamic simulation of a hybrid reactive separation process. Chemical Papers, 64, 193–202. DOI: 10.2478/s11696-009-0110-y.
Mitkowski, P. T., Buchaly, C., Kreis, P., Jonsson, G., Górak, A., & Gani, R. (2009a). Computer aided design, analysis and experimental investigation of membrane assisted batch reaction-separation systems. Computers & Chemical Engineering, 33, 551–574. DOI: 10.1016/j.compchemeng.2008.07. 012.
Mitkowski, P. T., Gani, R., & Broniarz-Press, L. (2009b). Novel membrane database in chemical process design. In Proceedings of the 8th World Congress of Chemical Engineering, 23–27 August 2009 (Paper No. 687, pp. 1–6). Montreal, QC, Canada.
Mulder, M., (1996). Basic principles of membrane technology (2nd ed.). Dordrecht, The Netherlands: Kluwer Academic.
Nielsen, T. L., Abildskov, J., Harper, P. M., Papaeconomou, I., & Gani, R. (2001). The CAPEC database. Journal of Chemical & Engineering Data, 46, 1041–1044. DOI: 10.1021/je000244z.
Parulekar, S. J. (2007). Analysis of pervaporation-aided esterification of organic acids. Industrial & Engineering Chemistry Research, 46, 8490–8504. DOI: 10.1021/ie061157o.
Pérez Cisneros, E. S., Gani, R., & Michelsen, M. L. (1997). Reactive separation systems—I. Computation of physical and chemical equilibrium. Chemical Engineering Science, 52, 527–543. DOI: 10.1016/S0009-2509(96)00424-1.
Sales-Cruz, M., & Gani, R. (2003). A modelling tool for different stages of the process life. In S. P. Asprey, & S. Macchietto (Eds.), Computer aided chemical engineering (Vol. 16, pp. 209–249). Amsterdam, The Netherlands: Elsevier. DOI: 10.1016/S1570-7946(03)80076-7.
Schmidt-Traub, H., & Górak, A. (2006). Integrated reaction and separation operations: Modelling and experimental operations. Berlin, Heidelberg, Germany: Springer-Verlag.
Sigma-Aldrich (2010). Product catalog. Retrieved March 11, 2011, from www.sigmaaldrich.com
Van Baelen, D., Van der Bruggen, B., Van den Dungen, K., Degreve, J., & Vandecasteele, C. (2005). Pervaporation of water-alcohol mixtures and acetic acid-water mixtures. Chemical Engineering Science, 60, 1583–1590. DOI: 10.1016/j.ces.2004.10.030.
Vu, D. T., Lira, C. T., Asthana, N. S., Kolah, A. K., & Miller, D. J. (2006). Vapor-liquid equilibria in the systems ethyl lactate + ethanol and ethyl lactate + water. Journal of Chemical & Engineering Data, 51, 1220–1225. DOI: 10.1021/je050537y.
Whu, J. A., Baltzis, B. C., & Sirkar, K. K. (1999). Modelling of nanofiltration — assisted organic synthesis. Journal of Membrane Science, 163, 319–331. DOI: 10.1016/S0376-7388(99)00175-1.
Zhang, Y., Ma, L., & Yang, J. (2004). Kinetics of esterification of lactic acid with ethanol catalyzed by cation-exchange resins. Reactive and Functional Polymers, 61, 101–114, DOI: 10.1016/j.reactfunctpolym.2004.04.003.
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Mitkowski, P.T. Hybrid process scheme for the synthesis of ethyl lactate: conceptual design and analysis. Chem. Pap. 65, 412–426 (2011). https://doi.org/10.2478/s11696-011-0036-z
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DOI: https://doi.org/10.2478/s11696-011-0036-z