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Chemical Papers

, Volume 65, Issue 3, pp 308–314 | Cite as

Synthesis, molecular characterisation, and in vivo study of platinum(IV) coordination compounds against B16 mouse melanoma tumours

  • Iwona ŁakomskaEmail author
  • Anna Kaźnica
  • Romana Joachimiak
  • Andrzej Marszałek
  • Jerzy Sitkowski
  • Lech Kozerski
  • Tomasz Drewa
Original Paper

Abstract

A novel platinum(IV) coordination compound with 6-mercaptopurine (6-Hmp) has been synthesised and characterised by IR and NMR spectroscopy. Spectroscopic parameters indicate the presence of two chelate (S-6, N-7) monodeprotonated ligands and two chloride ions in the coordination sphere of [PtCl2(6-mp)2] · H2O (I). Two Pt(IV) coordination compounds, [PtCl2(6-mp)2] · H2O (I) and [PtCl4(dbtp)2] (II), were used in the in vivo test against B16 mouse melanoma tumours. Cytotoxic activity of compound II against the tumour cells was found to be high (LC10 = 2.6 μM, LC50 = 17.0 μM, LC90 = 58.0 μM) compared to that of cisplatin.

Keywords

platinum(IV) complexes purine analogues NMR cytotoxicity in vivo melanoma 

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Copyright information

© Institute of Chemistry, Slovak Academy of Sciences 2011

Authors and Affiliations

  • Iwona Łakomska
    • 1
    Email author
  • Anna Kaźnica
    • 2
  • Romana Joachimiak
    • 2
  • Andrzej Marszałek
    • 3
  • Jerzy Sitkowski
    • 4
  • Lech Kozerski
    • 4
  • Tomasz Drewa
    • 2
  1. 1.Faculty of ChemistryNicolaus Copernicus UniversityToruńPoland
  2. 2.Chair of Medical BiologyNicolaus Copernicus UniversityBydgoszczPoland
  3. 3.Department of Clinical PathomorphologyNicolaus Copernicus UniversityBydgoszczPoland
  4. 4.National Institute of Public HealthWarsawPoland

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