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Chemical Papers

, Volume 64, Issue 4, pp 537–540 | Cite as

A novel method for N-alkylation of aliphatic amines with ethers over γ-Al2O3

  • Hangeng Chen
  • Tao Zhang
  • Chao QianEmail author
  • Xinzhi Chen
Short Communication

Abstract

A novel and simple method for the N-alkylation of amines with different ethers as alkylating reagents has been developed, using cheap γ-Al2O3 as the catalyst at atmospheric pressure in the temperature range of 260–320°C. For example, the reaction of equimolar amounts of morpholine and diethyl ether gave N-ethylmorpholine quantitatively. The present catalytic system is applicable to the N-alkylation of both primary and secondary amines. Since only water is generated as byproduct, the protocol proved to be eco-friendly and atom-economic.

Keywords

ethers amines N-alkylation atom-economic 

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Copyright information

© Institute of Chemistry, Slovak Academy of Sciences 2010

Authors and Affiliations

  • Hangeng Chen
    • 1
    • 2
  • Tao Zhang
    • 1
  • Chao Qian
    • 1
    Email author
  • Xinzhi Chen
    • 1
  1. 1.Department of Chemical and Biochemical EngineeringZhejiang UniversityHangzhouChina
  2. 2.SINOPEC Jinling CompanyNanjingChina

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