Synthesis of brushite nanoparticles at different temperatures
- 288 Downloads
Phase pure, stable nanocrystalline brushite particles with average diameter in the range of 23–87 nm were obtained by the reverse microemulsion technique employing a mixture of surfactants (Aliquat 336 & Tween 80) as template directing agents, and calcium nitrate tetrahydrate and biammonium hydrogen phosphate as precursors. Particle sizes and morphologies were tuned by adjusting the reaction parameters, precursor concentration and temperature. FTIR, TEM, and XRD were used to characterize morphological changes of as synthesized nanoparticles. FTIR and XRD analyses confirmed the formation of brushite nanoparticles. Variations in the reaction temperature resulted in changes in the particle morphology and distribution. At high temperatures (60°C), the sample exhibited high monodispersity and spherical morphology with the average grain size of 42 nm. At low temperatures (6°C), nanoflakes were formed. The results suggest that a reverse microemulsion system provides facile media for control of the phase and morphology of nanoscale calcium phosphate biominerals. A mechanism providing an insight into the formation of brushite particles has also been proposed.
Keywordsreverse microemulsion brushite mixed surfactants nanoparticle morphology
Unable to display preview. Download preview PDF.
- Bailey, R. T., & Holt, C. (1989). Fourier transform infrared spectroscopy and characterization of biological calcium phosphates. In D. W. L. Huskins (Ed.), Calcified tissue (pp. 93–119). Boca Raton, FL, USA: CRC Press.Google Scholar
- Kumar, M., Dasarathy, H., & Riley, C. (1999a) Electrodeposition of brushite coatings and their transformation to hydroxyapatite in aqueous solutions. Journal of Biomedical and Materials Research, 45, 302–310. DOI: 302-310.10.1002/(SICI)1097-4636(19990615)45:4<302::AID-JBM4>3.0.CO;2-A.CrossRefGoogle Scholar
- Roop Kumar, R., Prakash, K. H., Yennie, K., Cheang, P., & Khor, K. A. (2005) Synthesis and characterisation of hydroxyapatite nano-rods/whiskers. Key Engineering Materials, 284–286, 59–62. DOI: 10.4028/www.scientific.net/KEM.284-286.59.Google Scholar
- Sainz-Díaz, C. I., Villacampa, A., & Otálora, F. (2004) Crystallographic properties of the calcium phosphate mineral, brushite, by means of First Principles calculations. American Mineralogist, 89, 307–313.Google Scholar
- Xu, J., Butler, I. S., & Gilson, D. F. R. (1999) FT-Raman and high-pressure infrared spectroscopic studies of dicalcium phosphate dihydrate (CaHPO4·2H2O) and anhydrous dicalcium phosphate (CaHPO4). Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 55, 2801–2809. DOI: 10.1016/S1386-1425(99)00090-6.CrossRefGoogle Scholar