Skip to main content
Log in

In vitro antifungal and antibacterial properties of thiodiamine transition metal complexes

  • Original Paper
  • Published:
Chemical Papers Aims and scope Submit manuscript

Abstract

Synthesis, characterization and biological studies of some thiodiamine metal complexes are described. Cobalt(II) and copper(II) complexes of type [Cu(L)2Cl2] and [Co(L)2SO4], where L = (cyclohexyl-N-thio)-1,2-ethylenediamine (L1) and (cyclohexyl-N-thio)-1,3-propanediamine (L2), were synthesized. The synthesized copper and cobalt thiodiamine complexes were characterized by elemental analysis, IR, mass, UV-VIS and 1H NMR spectroscopic studies. Thiodiamines coordinate as a bidentate N-S ligand. The binding sites are azomethine nitrogen and thioamide sulfur. Molar conductance values in dimethylsulfoxide indicate non-electrolyte nature of the complexes. In vitro-antimicrobial screening shows promising results against both bacterial and fungal strains.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Aggarwal, R. C., & Rao, T. R. (1978). Synthesis and structural studies of some first row transition metal complexes of acetone isonicotinoyl hydrazone. Journal of Inorganic and Nuclear Chemistry, 40, 171–174. DOI: 10.1016/0022-1902(78)80334-0.

    Article  CAS  Google Scholar 

  • Ali, M. A., & Livingstone, S. E. (1974). Metal complexes of sulphur-nitrogen chelating agents. Coordination Chemistry Reviews, 13, 101–132. DOI: 10.1016/S0010-8545(00)80253-2.

    Article  CAS  Google Scholar 

  • Ali, M. A., Mirza, A. H., Butcher, R. J., Tarafder, M. T. H., & Ali, M. A. (2001). Synthetic, spectroscopic, biological and X-ray crystallographic structural studies on a novel pyridine-nitrogen-bridged dimeric nickel(II) complex of a pentadentate N3S2 ligand. Inorganica Chimica Acta, 320, 1–6. DOI: 10.1016/S0020-1693(01)00452-2.

    Article  Google Scholar 

  • Biswas, G. D, Biswas, P. K., & Chaudhuri, N. R. (1984). Conformational changes of nickel(II) diamine complexes in the solid state. Journal of Chemical Society, Dalton Transactions, 1984, 2591–2598. DOI: 10.1039/DT9840002591.

    Article  Google Scholar 

  • Choudhary, R. K., Yadav, S. N., Tiwari, H. N., & Mishra, L. K. (1998). Structural aspects of morpholine-N-thiohydrazones complexes with some bivalent metals. Journal of Indian Chemical Society, 75, 392–394.

    CAS  Google Scholar 

  • Eldeen, I. M. S., Elgorashi, E. E., & van Staden, J. (2005). Antibacterial, anti-inflammatory, anti-cholinesterase and mutagenic effects of extracts obtained from some trees used in South African traditional medicine. Journal of Ethnopharmacology, 102, 457–464. DOI: 10.1016/j.jep.2005.08.049.

    Article  CAS  Google Scholar 

  • Kaushik, N. K., & Mishra, A. K. (2003). Synthesis, characterization and thermal studies of some new organotion (iv) complexes with aniline N-thiohydrazide and benzaldehyde aniline N-thiohydrazone ligands. Indian Journal of Chemistry, 42, 2762–2766.

    Google Scholar 

  • Mishra, A. K., Mishra, S. B., Manav, N., Saluja, D., Chandra, R., & Kaushik, N. K. (2006a). Synthesis, characterization, antibacterial and cytotoxic study of platinum (IV) complexes. Bioorganic and Medicinal Chemistry, 14, 6333–6340. DOI: 10.1016/j.bmc.2006.05.047.

    Article  CAS  Google Scholar 

  • Mishra, A. K., Mishra, S. B., Manav, N., & Kaushik, N. K. (2006b). Preparation, spectral characterization, cytotoxic and thermal studies of platinum (IV) thiohydrazone complexes. Journal of Thermal Biology, 31, 611–616. DOI: 10.1016/j.jtherbio.2006.07.003.

    Article  CAS  Google Scholar 

  • Mishra, A. K., & Kaushik, N. K. (2007). Synthesis, characterization, cytotoxicity, antibacterial and antifungal evaluation of some new platinum (IV) and palladium (II) complexes of thiodiamines. European Journal of Medicinal Chemistry, 42, 1239–1246. DOI: 10.1016/j.ejmech.2007.03.017.

    Article  CAS  Google Scholar 

  • Mishra, A. K., Mishra, S. B., Manav, N., Kumar, R., Sharad, R., Chandra, R., Saluja, D., & Kaushik, N. K. (2007). Platinum(IV) thiohydrazide, thiodiamine and thiohydrazone complexes: A spectral, antibacterial and cytotoxic study. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 66, 1042–1047. DOI: 10.1016/j.saa.2006.04.038.

    Article  CAS  Google Scholar 

  • Padhyé, S., & Kauffman, G. B. (1985). Transition metal complexes of semicarbazones and thiosemicarbazones. Coordination Chemistry Reviews, 63, 127–160. DOI: 10.1016/0010-8545(85)80022-9.

    Article  Google Scholar 

  • Rajesh, & Sharma, G. L. (2002). Studies on antimycotic properties of Datura metal. Journal of Ethnopharmacology, 80, 193–197. DOI: 10.1016/S0378-8741(02)00036-3.

    Article  CAS  Google Scholar 

  • Singh, N. K., Srivastava, A., Sodhi, A., & Ranjan, P. (2000). In vitro and in vivo antitumour studies of a new thiosemicarbazide derivative and its complexes with 3d-metal ions. Transition Metal Chemistry, 25, 133–140. DOI: 10.1023/A:1007081218000.

    Article  CAS  Google Scholar 

  • West, D. X., Nassar, A. A., El-Saied, F. A., & Ayad, M. I. (1999). Cobalt(II) complexes with 2-aminoacetophenone N(4)-substituted thiosemicarbazones. Transition Metal Chemistry, 24, 617–621. DOI: 10.1023/A:1006988320142.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Ajay K. Mishra.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Mishra, A.K., Mishra, S.B. & Kaushik, N.K. In vitro antifungal and antibacterial properties of thiodiamine transition metal complexes. Chem. Pap. 63, 543–547 (2009). https://doi.org/10.2478/s11696-009-0049-z

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.2478/s11696-009-0049-z

Keywords

Navigation