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Simultaneous spectrophotometric determination of minoxidil and tretinoin by the H-point standard addition method and partial least squares

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Abstract

A simple, sensitive and selective spectrophotometric method for simultaneous determination of tretinoin and minoxidil using partial least square (PLS) calibration and H-point standard addition method (HPSAM) is described. The results of the H-point standard addition method show that minoxidil and tretinoin can be determined simultaneously with the concentration ratio of tretinoin to minoxidil varying from 2: 1 to 1: 33 in mixed samples. A partial least squares multivariate calibration method for the analysis of binary mixtures of tretinoin and minoxidil was also developed. The total relative standard error for applying the PLS method to eleven synthetic samples in the concentration range of 0–10 μg mL−1 tretinoin and 0–32 μg mL−1 minoxidil was 2.59 %. Both proposed methods (PLS and HPSAM) were also successfully applied in the determination of tretinoin and minoxidil in several synthetic pharmaceutical solutions.

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Authors and Affiliations

  1. Department of Chemistry, Islamic Azad University, Qom-Branch, Qom, Iran

    Maryam Bordbar, Mohammad Mahdi Ahari-Mostafavi & Mohammad Taghi Baharifard

  2. Department of Chemistry, Hamadan payame Noor University, Hamadan, Iran

    Ali Yeganeh-Faal

  3. Department of Chemistry, Faculty of Science, Razi University, Kermanshah, Iran

    Jahanbakhsh Ghasemi

  4. Department of Chemistry, Lorestan University, Khoram Abad, Iran

    Nahid Sarlak

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  1. Maryam Bordbar
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  2. Ali Yeganeh-Faal
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  3. Jahanbakhsh Ghasemi
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  4. Mohammad Mahdi Ahari-Mostafavi
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  5. Nahid Sarlak
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  6. Mohammad Taghi Baharifard
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Correspondence to Maryam Bordbar.

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Bordbar, M., Yeganeh-Faal, A., Ghasemi, J. et al. Simultaneous spectrophotometric determination of minoxidil and tretinoin by the H-point standard addition method and partial least squares. Chem. Pap. 63, 336–344 (2009). https://doi.org/10.2478/s11696-009-0003-0

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