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Synthesis of new thiazolo[2,3-b]pyrimidine derivatives of pharmaceutical interest

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Abstract

2H-5-Amino-6-cyano-3,7-dioxothiazolo[2,3-b]pyrimidine was subjected to ring formation affording thiazolo[2,3-b]pyrimidine derivatives. 2H-5-Amino-6-cyano-3,7-dioxo-2-phenylmethylenethiazolo[2,3-b]pyrimidine was also subjected to ring formation affording pyrimido[4,5-d]-, pyrano[2,3-d]-, and pyrido[2,3-d]thiazolo[2,3-b]pyrimidine derivatives. 2-Anilinothiocarbonyl-3,9-dioxo-8-imino-7-phenyl-6-thioxothiazolo[2,3-b]pyrimido[4,5-d]pyrimidine and 8-amino-3,9-dioxo-6-thioxothiazolo[2,3-b]pyrimido[4,5-d]pyrimidine reacted with α-haloactive-methylene compounds to afford heterocyclic compounds containing two, fused and isolated, thiazole moieties, respectively.

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  1. Chemistry Department, Faculty of Science, Mansoura University, New Damietta, 34517, Egypt

    H. H. Abdel-Razik

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  1. H. H. Abdel-Razik
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Abdel-Razik, H.H. Synthesis of new thiazolo[2,3-b]pyrimidine derivatives of pharmaceutical interest. Chem. Pap. 60, 268–273 (2006). https://doi.org/10.2478/s11696-006-0046-4

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  • DOI: https://doi.org/10.2478/s11696-006-0046-4

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