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Anthelmintic resistance in parasites of small ruminants: sheep versus goats

  • Review Article
  • Published:
Helminthologia

Summary

Anthelmintic resistance among parasites of sheep and goats has been known to occur for at least four decades. Both species of host have similar genera of nematodes, but the nematodes in goat herds usually develop anthelmintic resistance more rapidly. In vitro tests show higher ED50 values in goats than in flocks of sheep. Sheep and goats differ in many ways; for example, goats have a higher metabolic rate and require higher dose rates for drugs. The immune system of goats is also different. Additionally, these animals are reared under different management systems, i.e. sheep graze pastures and goats browse bushes, and lambing/kidding periods are different. Most anthelmintics used in goats have not been licensed for this animal species, and correct dose rates have rarely been experimentally determined. Possible explanations for such differences are discussed.

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References

  • Álvarez-Sánchez, M. A., Pérez-García, J., Cruzrojo, M. A., Rojo-Vázquez, F. A. (2005): Real time PCR for the diagnosis of benzimidazole resistance in trichostrongylids of sheep. Vet. Parasitol., 129: 291–298. DOI: 10.1016/j.vetpar.2005.02.004

    Article  PubMed  Google Scholar 

  • Amarante, A. F. T., Pomroy, W. E., Charleston, A. G., Leathwick, D. M., Tornero, M. T. T. (1997): Evaluation of larval development assay for the detection of anthelmintic resistance in Ostertagia circumcincta. Int. J. Parasitol., 27, 305–311. DOI: 10.1016/S0020-7519(96)00183-X

    Article  PubMed  CAS  Google Scholar 

  • Artho, R., Schnyde, R., M., Kohler, L., Torgerson, P. R., Hertzberg, H. (2007): Avermectin-resistance in gastrointestinal nematodes of Boer goats and Dorper sheep in Switzerland. Vet. Parasitol., 144: 68–73. DOI: 10.1016/j.vetpar.2006.09.032

    Article  PubMed  CAS  Google Scholar 

  • Bartley, D. J., Jackson, E., Johnston, K., Coop, R. L., Mitchell, G. B. B., Sales, J., Jackson, F. (2003): A survey of anthelmintic resistant nematode parasites in Scottish sheep flocks. tVet. Parasitol., 117: 61–71. DOI: 10.1016/j.vetpar.2003.07.023

    Article  Google Scholar 

  • Bauer, C. (1988): Anthelmintic resistance of nematodes from cattle, sheep and goats. Zentralbl. Veterinarmed. B., 35: 286–300. DOI: 10.1111/j.1439-0450.1988.tb00499.x

    PubMed  CAS  Google Scholar 

  • Bauer, C. (2001): Multispecific resistance of trichostrongyles to benzimidazoles in a goat herd in Germany. Dtsch. Tierärtzl. Wochensch., 108: 49–50

    CAS  Google Scholar 

  • Bennett, J. L., Pax, R. A. (1986): Micromotility meter: an instrument designed to evaluate the action of drugs on motility of larval and adult nematodes. Parasitol., 93: 341–346. DOI: 10.1017/S0031182000051507

    Article  CAS  Google Scholar 

  • Besier, B. (2007): New anthelmintics for livestock: the time is right. Trends Parasitol., 23: 21–24. DOI: 10.1016/j.pt.2006.11.004

    Article  PubMed  CAS  Google Scholar 

  • Boersema, J. H, Borgsteede, F. H. M., Eysker, M., Hendrikx, W. M. L., Jansen, J., Smith-Buys, C. M. C. (1987): Prevalence of benzimidazol resistance of nematodes in sheep in The Netherlands. Res. Vet. Sci., 43: 18–21

    PubMed  CAS  Google Scholar 

  • Cawthorne, R. J. G., Cheong, F. H. (1984): Prevalence of anthelmintic resistant nematodes in sheep in south-east England. Vet. Rec., 114: 562–564. DOI: 10.1136/vr.114.2 3.562

    Article  PubMed  CAS  Google Scholar 

  • Chandrawathani, P., Yussof, N., Waller, P. J. (2004): Total anthelmintic failure to control nematode parasites of small ruminants on government breeding farms in Sabah, east Malaysia. Vet. Res. Comm., 28: 479–489. DOI: 10.1023/B:VERC.0000040240.69004.dc

    Article  CAS  Google Scholar 

  • Charles, T. P., Pompeu, J., Miranda, D. B. (1989): Efficacy of three broad-spectrum anthelmintics against gastrointestinal nematode infections of goats. Vet. Parasitol., 34: 71–75. DOI: 10.1016/0304-4017(89)90166-0

    Article  PubMed  CAS  Google Scholar 

  • Chartier, C., Hoste, H. (1994): Anthelmintic treatments against digestive-tract nematodes in grazing dairy goats with high or low levels of milk production. Vet. Res., 25: 450–457

    PubMed  CAS  Google Scholar 

  • Chartier C., Soubirac F., Pors I., Silvestre, A., Hubert, J., Couquet, C., Cabaret, J. (2001): Prevalence of anthelmintic resistance in gastrointestinal nematodes of dairy goats under extensive management conditions in southwestern France. J. Helminthol., 75: 325–330. DOI: 10.1017/S0022149X01000506

    PubMed  CAS  Google Scholar 

  • Coles, G. C. (2004): Anthelmintic resistance - looking to the future: a UK perspective. Res. Vet. Sci., 78: 99–108. DOI: 10.1016/j.rvsc.2004.09.001

    Article  Google Scholar 

  • Coles, G. C., Bauer, C., Borgsteede, F. H. M., Geerts, S., Klei, T. R., Taylor, M. A., Waller, P. J. (1992): World Association for the Advancement of Veterinary Parasitology (W.A.A.V.P.) methods for the detection of anthelmintic resistance in nematodes of veterinary import ance. Vet. Parasitol., 44: 35–44. DOI: 10.1016/0304-4017(92)90141-U

    Article  PubMed  CAS  Google Scholar 

  • Coles, G. C., Jackson, F., Pomroy, W. E., Prichard, R. K., Von Samson-Himmelstjerna, G., Silvestre, A., Taylor, M. A., Vercruysse, J. (2006): The detection of anthelmintic resistance in nematodes of veterinary importance. Vet. Parasitol., 136: 167–185. DOI: 10.1016/j.vetpar.2005.11.019

    Article  PubMed  CAS  Google Scholar 

  • Coles, G. C., Tritschler Ii, J. J., Giordano, D. J., Laste, N. J., Schmidt, A. L. (1988): A larval development test for detection of anthelmintic resistant nematodes. Res. Vet. Sci., 45: 50–53

    PubMed  CAS  Google Scholar 

  • Cringoli, G., Veneziano, V., Rinaldi, L., Sauvé, C., Rubino, R., Fedele, V., Cabaret J. (2007): Resistance of trichostrongyles to benzimidazoles in Italy: a first report in a goat farm with multiple and repeated introductions. Parasitol. Res., 101: 577–581. DOI: 10.1007/s00436-007-0518-7

    Article  PubMed  CAS  Google Scholar 

  • Čudeková, P., Várady, M., Königová, A., Dolinská, M. (2010): Phenotypic and genotypic characterisation of benzimidazole susceptible and resistant isolates of Haemonchus contortus. Vet. Parasitol., 172: 155–159. DOI: 10.1016/j.vetpar.2010.04.022

    Article  PubMed  Google Scholar 

  • Dorny, P., Claerebout, E., Vercruysse, J., Sani, R., Jalila, A. (1994): Anthelmintic resistance in goats in peninsular Malaysia. Vet. Parasitol., 55: 327–342. DOI: 10.1016/0304-4017(94)90073-6

    Article  PubMed  CAS  Google Scholar 

  • Dorny, P., Symoens, C., Jalila, A., Vercruysse, J., Sani, R. (1995): Strongyle infections in sheep and goats under the traditional husbandry system in peninsular Malaysia. Vet. Parasitol., 56: 121–136. DOI: 10.1016/03 04-4017(94)00657-X

    Article  PubMed  CAS  Google Scholar 

  • Drudge, J. H., Szanto, J., Wyant, N. Z., Elam, G. (1964): Field studies on parasite control of sheep: Comparison of thiabendazole, ruelene and phenotiazine. Am. J. Vet. Res., 25: 1512–1518.

    PubMed  CAS  Google Scholar 

  • Gallidis, E., Papadopoulos, E., Ptochos, S., Arsenos, G. (2009): The use of targeted selective treatments against gastrointestinal nematodes in milking sheep and goats in Greece based on parasitological and performance criteria. Vet. Parasitol., 164: 53–58. DOI: 10.1016/j.vetpar.2009.04.011

    Article  PubMed  CAS  Google Scholar 

  • Gasnier, N., Cabaret, J. (1996): Evidence for a sheep and goat line of Teladorsagia circumcincta. Parasitol. Res., 82: 546–550. DOI: 10.1007/s004360050160

    Article  PubMed  CAS  Google Scholar 

  • Geary, T. G., Sims, S. M., Thomas, E. M., Vanover, L., Davis, J. P., Winterrowd, A., Klein, R. D., Ho, N. F. H., Thompson, D. P. (1993): Haemonchus contortus: ivermectin-induced paralysis of the pharynx. Exp. Parasitol., 77: 88–96. DOI: 10.1006/expr.1993.1064

    Article  PubMed  CAS  Google Scholar 

  • Gill, J. H., Redwin, J. H., Van Wyk, J. A., Lacey, E. (1991): Detection of resistance to ivermectin in Haemonchus contortus. Int. J. Parasitol., 21: 771–776. DOI: 10.1016/0020-7519(91)90144-V

    Article  PubMed  CAS  Google Scholar 

  • Gillham, R. J., Obendorf, D. L. (1985): Therapeutic failure of levemisole in dairy goats. Aust. Vet. J., 62: 426–427. DOI: 10.1111/j.1751-0813.1985.tb14132.x

    Article  PubMed  CAS  Google Scholar 

  • Hazelby, C. A., Probert, A. J. Rowlands, D. A. T. (1994): Anthelmintic resistance in nematodes causing parasitic gastroenteritis of sheep in the UK. J. Vet. Pharmacol. Ther., 17: 245–252. DOI: 10.1111/j.1365-2885.1994.tb00240.x

    Article  PubMed  CAS  Google Scholar 

  • Hennessy, D. R. (1994): The disposition of antiparasitic drugs in relation to the development of resistance by parasites of livestock. Acta Trop., 56: 125–141. DOI: 10.10 16/0001-706X(94)90059-0

    Article  PubMed  CAS  Google Scholar 

  • Hennessy, D. R., Sangster, N. C., Steel, J. W., Collins, G. H. (1993): Comparative pharmacokinetic behaviour of albendazole in sheep and goats. Int. J. Parasitol., 23: 321–325. DOI: 10.1016/0020-7519(93)90006-K

    Article  PubMed  CAS  Google Scholar 

  • Hertzberg H., Bauer C. (2000): Anthelminthika-Resistenzen bei Magen-Darm Strongyliden von Schafen und Ziegen: Aktuelles ueber Verbreitung, Epidemiologie, Vorbeugemaßnahmen und Alternativen zum Anthelminthika- Einsatz. Berl. Muench. Tieraerztl. Wsch., 113: 122–128.

    CAS  Google Scholar 

  • Hong, C., Hunt, K. R., Harris, T. J., Coles, G. C., Grimshaw, W. T., Mcmullin, P. F. (1992): A survey of benzimidazole resistant nematodes in sheep in three countries of southern England. Vet. Rec., 131: 5–7. DOI: 10.11 36/vr.131.1.5

    Article  PubMed  CAS  Google Scholar 

  • Hoste, H., Chartier, C. (1993): Comparison of the effects on milk production of concurrent infection with Haemonchus contortus and Trichostrongylus colubriformis in high- and low-producing dairy goats. Am. J. Vet. Res., 54: 1886–1893.

    PubMed  CAS  Google Scholar 

  • Hoste, H., Le Frileux, Y., Pommaret, A. (2001): Distribution and repeatability of faecal egg counts and blood parameters in dairy goats naturally infected with gastrointestinal nematodes. Res. Vet. Sci., 70: 57–60. DOI: 10.1053/rvsc.2000.0442

    Article  PubMed  CAS  Google Scholar 

  • Hoste, H., Leveque, H., Dorchies, P. (2001): Comparison of nematode infections of the gastrointestinal tract in Angora and dairy goats in a rangeland environment: relations with the feeding behaviour. Vet. Parasitol., 101: 127–135. DOI: 10.1016/S0304-4017(01)00510-6

    Article  PubMed  CAS  Google Scholar 

  • Hoste, H., Torres-acosta, J. F., Paolini, V., Aguilarcaballero, A., Etter, E., Lefrileux, Y., Chartier, C., Broqua, C. (2005): Interactions between nutrition and gastrointestinal infections with parasitic nematodes in goats. Small Rumin. Res., 60: 141–151. DOI: 10.1016/j.smallrumres.2005.06.008

    Article  Google Scholar 

  • Hoste, H., Torres-Acosta, J. F. J., Aguilarcaballero, A. J. (2008): Parasite interactions in goats: is immunoregulation involved in the control of gastrointestinal nematodes? Parasite Immunol., 30: 79–88. DOI: 10.1111/j.1365-3024.2007.00987.x

    PubMed  CAS  Google Scholar 

  • Hoste H., Sotiraki S., Landau S. Y. Jackson F., Beveridge I. (2010): Goat-Nematode interactions: think differently. Trends Parasitol., 26: 376–381. DOI: 10.1016/j.pt.2010.04.007

    Article  PubMed  Google Scholar 

  • Hubert, J., Kerboeuf, D. (1992): A microlarval development assay for the detection of anthelmintic resistance in sheep nematodes. Vet. Rec., 130: 442–446. DOI: 10.1136/vr.130.20.442

    Article  PubMed  CAS  Google Scholar 

  • Huntley, J. F., Patterson, M., Mackellar, A., Jackson, F., Stevenson, L. M., Coop, R. L. (1995): Gastro intestinal nematode infection in goats: comparison of mast cell and eosinophil responses with those of sheep. Res. Vet. Sci., 58: 5–10. DOI: 10.1016/0034-5288(95)90080-2

    Article  PubMed  CAS  Google Scholar 

  • Johansen, M. V. (1989): An evaluation of techniques used for the detection of anthelmintic resistance in nematode parasites of domestic livestock. Vet. Res. Commun., 13: 455–466. DOI: 10.1007/BF00402569

    Article  PubMed  CAS  Google Scholar 

  • Kanyari, P. W. N. (1993): The relationship between coccidial and helminth infections in sheep and goats in Kenya. Vet. Parasitol., 51: 137–141. DOI: 10.1016/0304-4017(93)90204-Z

    Article  PubMed  CAS  Google Scholar 

  • Kemp, G. K., Smith, C. F. (1982): Anthelmintic resistance survey in New Zealand. N. Z. Vet. J., 30: 141–144.

    Article  PubMed  CAS  Google Scholar 

  • Kotze, A. C., Dobson, R. J., Tyrrell, K. L., Stein, P. A. (2002): High-level ivermectin resistance in a field isolate of Haemonchus contortus associated with a low level of resistance in the larval stage: implications for resistance detection. Vet. Parasitol., 108: 255–263. DOI: 10.1016/S0304-4017(02)00200-5

    Article  PubMed  CAS  Google Scholar 

  • Kotze, A. C., LE Jambre, L. F., O’Grady, J. (2006): A modified larval migration assay for detection of resistance to macrocyclic lactones in Haemonchus contortus, and drug screening with Trichostrongylidae parasites. Vet. Parasitol., 137: 294–305. DOI: 10.1016/j.vetpar.2006.01.017

    Article  PubMed  CAS  Google Scholar 

  • Lacey, E., Redwin, J. M., Gill, G. H., Demargheriti, V. M., Waller, P. J. (1991): A larval development assay for the simultaneous detection of broad spectrum anthelmintic resistance. In: Boray, J. C., Martin, P. J., Roush, R. T. (Eds) Resistance of Parasites to Antiparasitic Drugs. MSD AGVET, Rahway, pp. 177–184

    Google Scholar 

  • le Jambre, L. F. (1976): Egg-hatch as in vitro assay of thiabendazole resistance in nematodes. Vet. Parasitol., 2: 385–391. DOI: 10.1016/0304-4017(76)90067-4

    Article  Google Scholar 

  • Le Jambre, L., Royal, W. M. (1976): A comparison of worm burdens in grazing Merino sheep and Angora goats. Aust. Vet. J., 52: 181–183. DOI: 10.1111/j.1751-0813.1976.tb09467.x

    Article  PubMed  Google Scholar 

  • Macaldowie, C., Jackson, F., Huntley, J., Mackellar, A., Jackson, E. (2003): A comparison of larval development and mucosal mast cell responses in worm-naïve goat yearlings, kids and lambs undergoing primary and secondary challenge with Teladorsagia circumcincta. Vet. Parasitol., 114: 1–13. DOI: 10.1016/S0304-4017(03)00110-9

    Article  PubMed  CAS  Google Scholar 

  • Maingi, N., Bjørn, H., Thamsborg, S. M., Bøgh, H. O., Nansen, P. (1996): A survey of anthelmintic resistance in nematode parasites of goats in Denmark. Vet. Parasitol., 66: 53–66. DOI: 10.1016/S0304-4017(96)01006-0

    Article  PubMed  CAS  Google Scholar 

  • Martin, P. J., Anderson, N., Jarrett, R. G. (1989): Detecting benzimidazole resistance with faecal egg count reduction tests and in vitro assays. Aust. Vet. J., 66: 236–240. DOI: 10.1111/j.1751-0813.1989.tb13578.x

    Article  PubMed  CAS  Google Scholar 

  • Martin, P. J., LE Jambre, L. F. (1979): Larval paralysis as an in vitro assay af levamisole and morantel tartrate resistance in Ostertagia. Vet. Res. Commun., 3: 159–164. DOI: 10.1007/BF02268963

    Article  Google Scholar 

  • Mckenna, P. B. (1984): Gastro-intestinal parasitism and anthelmintic resistance in goats. Surveillance, 11: 2–4

    Google Scholar 

  • Mckenna, P. B., Watson, T. G., 1987. The comparative efficacy of four broad spectrum anthelmintics against some experimentally induced trichostrongylid infections in sheep and goats. N. Z. Vet. J., 35: 192–195. DOI: 10.1080/00480169./1987.35443

    Article  PubMed  Google Scholar 

  • Mwamachi, D. M., Audho, J. O., Thorpe, W., Baker, R. L. (1995): Evidence for multiple anthelmintic resistance in sheep and goats reared under the same management in coastal Kenya. Vet. Parasitol., 60: 303–313. DOI: 10.1016/0304-4017(95)00794-1

    Article  PubMed  CAS  Google Scholar 

  • Overend, D. J., Phillips, M. L., Poulton, A. L., Foster, C. E. (1994): Anthelmintic resistance in Australian sheep nematode populations. Aust. Vet. J., 71: 117–121. DOI: 10.1111/j.1751-0813.1994.tb03352.x

    Article  PubMed  CAS  Google Scholar 

  • Papadopoulos, E. (2008): Anthelmintic resistance in sheep nematodes. Small Rumin. Res., 76: 99–103. DOI: 10.1016/j.smallrumres.2007.12.012

    Article  Google Scholar 

  • Papadopoulos, E., Himonas, C., Coles, G. C. (2001): Drought and flock isolation may enhance the development of anthelmintic resistance in nematodes. Vet. Parasitol., 97: 253–259. DOI: 10.1016/S0304-4017(01)00435-6

    Article  PubMed  CAS  Google Scholar 

  • Pomroy, W. E., Lambert, M. G., Betteridge, K. (1986): Comparison of faecal strongylate egg counts of goats and sheep on the same pasture. N. Z. Vet. J., 34: 36–37. DOI: 10.1080/00480169.1986.35272

    Article  PubMed  CAS  Google Scholar 

  • Praslicka, J., Varady, M., Corba, J., Vesely, L. (1994): The first survey of anthelmintic resistance in Slovakia. Vet. Parasitol., 52: 169–171. DOI: 10.1016/0304- 4017(94)90048-5

    Article  PubMed  CAS  Google Scholar 

  • Presidente, P. J. A. (1985): Methods for detection of nematode resistance to anthelmintic In: Anderson, N., Waller, P. J. (Eds) Resistance in nematodes to anthelmintics drug. CSIRO Melbourne, pp. 13–28.

  • Requejo-Fernández, J. A., Martínez, A., Meana, A. F. A., Rojo-Vázquez, F. A., Osoro, K., Ortega-Mora, L. M. (1997): Anthelmintic resistance in nematode parasites from goats in Spain. Vet. Parasitol., 73: 83–88. DOI: 10.1016/S0304-4017(97)00043-5

    Article  PubMed  Google Scholar 

  • Rohrer, S. P., Birzin, E. T., Eary, C. H., Schaeffer, J. M., Shoop, W. L. (1994): Ivermectin binding sites in sensitive and resistant Haemonchus contortus. J. Parasitol., 80: 493–497

    Article  PubMed  CAS  Google Scholar 

  • Rothwell, J. T., Sangster, N. C. (1993): An in vitro assay utilizing parasitic larval Haemonchus contortus to detect resistance to closantel and other anthelmintics. Int. J. Parasitol., 23: 573–578. DOI: 10.1016/0020- 7519(93)90162-R

    Article  PubMed  CAS  Google Scholar 

  • Silvestre, A., Humbert, J. F. (2000): A molecular tool for species identification and benzimidazole resistance diagnosis in larval communities of small ruminant parasites. Exp. Parasitol., 95: 271–276. DOI: 10.1006/expr.2000.4542

    Article  PubMed  CAS  Google Scholar 

  • Schnyder, M., Torgerson, P. R., Schoenmann, M., Kohler, L., Hertzberg, H. (2005): Multiple anthelmintic resistance in Haemonchus contortus isolated from South African Boer goats in Switzerland. Vet. Parasitol., 128: 285–290. DOI: 10.1016/j.vetpar.2004.12.010

    Article  PubMed  CAS  Google Scholar 

  • Sreter, T., Molnar, V., Kassai, T. (1994): The distribution of nematode egg counts and larval counts in grazing sheep and their implications for parasite control. Int. J. Parasitol., 24: 103–108. DOI: 10.1016/0020-7519(94)90 063-9

    Article  PubMed  CAS  Google Scholar 

  • Sutherland, I. A., Lee, D. L. (1989): Colorimetric assay for the detection of benzimidazole resistance in trichostrongyles. Res. Vet. Sci., 46: 363–366.

    PubMed  CAS  Google Scholar 

  • Sutherland, I. A., Lee, D. L. (1990): A larval paralysis assay for the detection of thiabendazole resistance in trichostrongyles. Parasitology, 100: 131–135. DOI: 10.1017/S0031182000060200

    Article  PubMed  CAS  Google Scholar 

  • Sutherland, I. A., Lee, D. L., 1993. Acetylcholinesterase in infective-stage larvae of Haemonchus contortus, Ostertagia circumcincta and Trichostrongylus colubriformis resistant and susceptible to benzimidazole anthelmintics. Parasitology, 107: 553–557. DOI: 10.1017/S003118200006813X

    Article  PubMed  CAS  Google Scholar 

  • Sutherland, I. A., Lee, D. L., Lewis, D. (1988): Detection of benzimidazole resistance in trichostrongylid nematodes. Parasitol. Today, 4: 22–24. DOI: 10.1016/0169-4758(88)90055-5

    Article  PubMed  CAS  Google Scholar 

  • Sutherland, I. A., Shaw, J., Shaw, R. J. (2010): The production costs of anthelmintic resistance in sheep managed within a monthly preventive drench program. Vet. Parasitol., 171: 300–304. DOI: 10.1016/j.vetpar.2010.03.035

    Article  PubMed  CAS  Google Scholar 

  • Sykes, A. (1994): Parasitism and production in farm animals. Anim. Prod., 59: 155–172. DOI: 10.1017/S0003356 100007649

    Article  Google Scholar 

  • Swan, G. E., Gross, S. J., 1985. Efficacy of ivermectin against induced gastrointestinal nematode infections in goats. Vet. Rec., 117: 147–149. DOI: 10.1136/vr.117.7.147

    Article  PubMed  CAS  Google Scholar 

  • Taylor, M. A. (1990): A larval development test for the detection of anthelmintic resistance in nematodes of sheep. Res. Vet. Sci., 49: 198–202.

    PubMed  CAS  Google Scholar 

  • Taylor, M. A., Hunt, K. R., Goodyear, K. L. (2002): Anthelmintic resistance detection methods. Vet. Parasitol., 103: 183–194. DOI: 10.1016/S0304-4017(01)00604-5

    Article  PubMed  CAS  Google Scholar 

  • Thomaz-Soccol, V., Souza, F. P., Sotomaior, C., Castro, E. A., Milczewski, V., Mocelin, G., Pessoa E Silva, M. C., 2004. Resistance of gastrointestinal nematodes to anthelmintics in sheep (Ovis aries). Brazil Arch. Biol. Technol., 47: 41–47. DOI: 10.1590/S1516-89132004000100006

    Article  Google Scholar 

  • van Wyk J. A., Stenson M. O., Merwe J. S, Van Der. Vorster R. J., Viljoen P. G. (1999): Anthelmintic resistance in South Africa: surveys indicate an extremely serious situation in sheep and goat farming. Onderstep. J.Vet. Res., 66: 273–284

    Google Scholar 

  • Várady, M., Corba, J. (1999): Comparison of six in vitro tests in determining benzimidazole and levamisole resistance in Haemonchus contortus and Ostertagia circumcincta of sheep. Vet. Parasitol., 80: 239–249. DOI: 10.1016/S0304-4017(98)00211-8

    Article  PubMed  Google Scholar 

  • Várady, M., Čerňanská, D., Čorba, J., 2006. Use of two in vitro methods for the detection of anthelmintic resistant nematode parasites on Slovak sheep farms. Vet. Parasitol., 135: 325–331. DOI: 10.1016/j.vetpar.2005.10.006

    Article  PubMed  Google Scholar 

  • Várady, M., Čudeková, P., Čorba, J. (2007): In vitro detection of benzimidazole resistance in Haemonchus contortus: Egg hatch test versus Larval development test. Vet. Parasitol., 149: 104–110. DOI: 10.1016/j.vetpar.2007.07.011

    Article  PubMed  Google Scholar 

  • Várady, M., Praslička, J., Corba, J. (1994) Treatment of multiple resistant field strain of Ostertagia spp. in cashmere and angora goats. Int. J. Parasitol., 24: 335–340. DOI: 10.1016/0020-7519(94)90080-9

    Article  PubMed  Google Scholar 

  • Vercruysse, J. (1983): A survey of seasonal changes in nematode faecal egg count level of sheep and goats in Senegal. Vet. Parasitol., 13: 239–244. DOI: 10.1016/03 04-4017(83)90060-2

    Article  PubMed  CAS  Google Scholar 

  • Von Samson-Himmelstjerna, G., Walsh, T. K., Donnan, A. A., Carrière, S., Jackson, F., Skuce, P. J., Rohn, K., Wolstenholme, A. J. (2009): Molecular detection of benzimidazole resistance in Haemonchus contortus using real-time PCR and pyrosequencing. Parasitology, 136: 349–358. DOI: 10.1017/S003118200800543X

    Article  Google Scholar 

  • Wagland, B. M., Jones, W. O., Hribar, L., Bendixsen, T., Emery, D. L. (1992): A new simplified assay for larval migration inhibition. Int. J. Parasitol., 22: 1183–1185. DOI: 10.1016/0020-7519(92)90040-R

    Article  PubMed  CAS  Google Scholar 

  • Walsh, T. K., Donnan, A. A., Jackson, F., Skuce, P., Wolstenholme, A. J. (2007): Detection and measurement of benzimidazole resistance alleles in Haemonchus contortus using real-time PCR with locked nucleic acid Taqman probes. Vet. Parasitol., 144: 304–312. DOI: 10.1016/j.vetpar.2006.10.014

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Institute of Parasitology, Slovak Academy of Sciences, Kosice, Slovakia

    M. Várady, M. Dolinská & A. Königová

  2. Laboratory of Parasitology and Parasitic Diseases, Faculty of Veterinary Medicine, Aristotle University, Thessaloniki, Greece

    E. Papadopoulos

Authors
  1. M. Várady
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  2. E. Papadopoulos
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  3. M. Dolinská
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  4. A. Königová
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Correspondence to M. Várady.

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Várady, M., Papadopoulos, E., Dolinská, M. et al. Anthelmintic resistance in parasites of small ruminants: sheep versus goats. Helminthologia 48, 137–144 (2011). https://doi.org/10.2478/s11687-011-0021-7

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  • DOI: https://doi.org/10.2478/s11687-011-0021-7

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