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Seroprevalence of Neospora caninum Infection in Dog Population Worldwide: A Systematic Review and Meta-analysis

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Abstract

Purpose

Neospora caninum is an obligate intracellular apicomplexan protozoan that causes neurological disorders in dogs. This systematic review and meta-analysis targeted at evaluating the worldwide seroprevalence rate of N. caninum in dogs.

Methods

Five electronic databases, including PubMed, Scopus, Web of Science, Science Direct, and Google Scholar, until December 2018 were thoroughly searched for relevant English language articles. Papers were selected based on inclusion criteria. Data were analyzed in StatsDirect statistical software (version 2.7.9).

Results

The searching process yielded a total number of 156 papers. The total prevalence (95% confidence intervals) of N. caninum infection in dog population worldwide was measured as 17.14% in data analyses (15.25–19.10). In addition, a significant association was also detected between neosporosis infection in dogs and continent, country, year, WHO regions, sample size and diagnostic method (P < 0.001).

Conclusion

Dogs are a matter of concern to public health officials as a source of N. caninum infection. Therefore, it is of paramount importance to provide comprehensive data and systematically analyze the prevalence of N. caninum infection in dogs. Accordingly, it is recommended that researchers carry out further studies to prevent and control neosporosis among dog population worldwide.

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Acknowledgements

This work was supported by a Grant (No. 4781) from the Deputy of Research, Mazandaran University of Medical Sciences, Sari, Iran.

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Authors and Affiliations

  1. Student Research Committee, Mazandaran University of Medical Science, Sari, Iran

    Davood Anvari & Reza Saberi

  2. Toxoplasmosis Research Center, Department of Parasitology, School of Medicine, Mazandaran University of Medical Sciences, 18th Km of Khazar Abad Road, Sari, Iran

    Davood Anvari, Mehdi Sharif, Shahabbedin Sarvi, Seyed Abdollah Hosseini, Zahra Hosseininejad, Tooran Nayeri Chegeni & Ahmad Daryani

  3. Health Science Research Center, Addiction Institute, Mazandaran University of Medical Sciences, Sari, Iran

    Mahmood Moosazadeh

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  1. Davood Anvari
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Contributions

AD designed all steps of the study with the help of SS and MS. DA and RS were involved in the database search, data extraction, and writing—original draft. SAH, MM and DA analyzed the results. ZH and TNC carried out the screen of the literature and data extraction. The manuscript was written by DA and RS, and finally revised by AD. All authors read and approved the final manuscript.

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Correspondence to Ahmad Daryani.

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Anvari, D., Saberi, R., Sharif, M. et al. Seroprevalence of Neospora caninum Infection in Dog Population Worldwide: A Systematic Review and Meta-analysis. Acta Parasit. 65, 273–290 (2020). https://doi.org/10.2478/s11686-019-00163-4

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