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Characterization of polymeric system for cisplatin delivery — analytical methods for Pt determination

Central European Journal of Chemistry volume 11, pages 1548–1553 (2013)Cite this article

Abstract

Cis-diamminedichloroplatinum(II) (cisplatin) was immobilized in a star-shaped polymer carrier. In order to define whether this polymer could be used as a drug delivery system for cisplatin, its characteristics, e.g. loading efficiency and release profile of cisplatin from the polymer in phosphate buffered saline (PBS), have to be assessed, and hence an appropriate analytical procedure for precise and reliable determination of Pt(II) must be established. Optimal instrumental parameters for Pt measurement by commonly used atomic spectrometric methods ETAAS and ICP-OES in various examined media were defined. Matrix interferences observed that were related to both techniques were evaluated, and analytical figures of merit were compared and critically discussed.

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Authors and Affiliations

  1. Faculty of Chemistry and Pharmacy, Sofia University “St. Kliment Ohridski, 1164, Sofia, Bulgaria

    Ekaterina V. Stoyanova & Irina B. Karadjova

  2. Geological Institute, Bulgarian Academy of Sciences, 1113, Sofia, Bulgaria

    Methody G. Karadjov

  3. Institute of Polymers, Bulgarian Academy of Sciences, 1113, Sofia, Bulgaria

    Ekaterina V. Stoyanova & Neli S. Koseva

Authors
  1. Ekaterina V. Stoyanova
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  2. Irina B. Karadjova
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  3. Methody G. Karadjov
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  4. Neli S. Koseva
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Correspondence to Irina B. Karadjova.

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Stoyanova, E.V., Karadjova, I.B., Karadjov, M.G. et al. Characterization of polymeric system for cisplatin delivery — analytical methods for Pt determination. cent.eur.j.chem. 11, 1548–1553 (2013). https://doi.org/10.2478/s11532-013-0278-4

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  • DOI: https://doi.org/10.2478/s11532-013-0278-4

Keywords

  • Pt
  • ETAAS
  • ICP-OES
  • Polymer drug
  • Phosphate buffered saline