Characterization of polymeric system for cisplatin delivery — analytical methods for Pt determination
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Cis-diamminedichloroplatinum(II) (cisplatin) was immobilized in a star-shaped polymer carrier. In order to define whether this polymer could be used as a drug delivery system for cisplatin, its characteristics, e.g. loading efficiency and release profile of cisplatin from the polymer in phosphate buffered saline (PBS), have to be assessed, and hence an appropriate analytical procedure for precise and reliable determination of Pt(II) must be established. Optimal instrumental parameters for Pt measurement by commonly used atomic spectrometric methods ETAAS and ICP-OES in various examined media were defined. Matrix interferences observed that were related to both techniques were evaluated, and analytical figures of merit were compared and critically discussed.
KeywordsPt ETAAS ICP-OES Polymer drug Phosphate buffered saline
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- A.F. LeRoy, R.J. Lutz, R.L. Dedrick, C.L. Litterst, A.M. Guarino, Cancer Treat. Rep. 63, 59 (1979)Google Scholar
- R. Miller, J. Doerger, Atomic Abs. Newsletter 14, 66 (1975)Google Scholar
- P. Ash, Platinum Metals Rev. 3, 52 (2008)Google Scholar
- Y. Matsumura, H. Maeda, Cancer Res. 46, 6387 (1986)Google Scholar