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Central European Journal of Chemistry

, Volume 11, Issue 9, pp 1548–1553 | Cite as

Characterization of polymeric system for cisplatin delivery — analytical methods for Pt determination

  • Ekaterina V. Stoyanova
  • Irina B. KaradjovaEmail author
  • Methody G. Karadjov
  • Neli S. Koseva
Research Article
  • 92 Downloads

Abstract

Cis-diamminedichloroplatinum(II) (cisplatin) was immobilized in a star-shaped polymer carrier. In order to define whether this polymer could be used as a drug delivery system for cisplatin, its characteristics, e.g. loading efficiency and release profile of cisplatin from the polymer in phosphate buffered saline (PBS), have to be assessed, and hence an appropriate analytical procedure for precise and reliable determination of Pt(II) must be established. Optimal instrumental parameters for Pt measurement by commonly used atomic spectrometric methods ETAAS and ICP-OES in various examined media were defined. Matrix interferences observed that were related to both techniques were evaluated, and analytical figures of merit were compared and critically discussed.

Graphical abstract

Keywords

Pt ETAAS ICP-OES Polymer drug Phosphate buffered saline 

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Supplementary material

11532_2013_278_MOESM1_ESM.pdf (187 kb)
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Copyright information

© Versita Warsaw and Springer-Verlag Wien 2013

Authors and Affiliations

  • Ekaterina V. Stoyanova
    • 1
    • 3
  • Irina B. Karadjova
    • 1
    Email author
  • Methody G. Karadjov
    • 2
  • Neli S. Koseva
    • 3
  1. 1.Faculty of Chemistry and PharmacySofia University “St. Kliment OhridskiSofiaBulgaria
  2. 2.Geological InstituteBulgarian Academy of SciencesSofiaBulgaria
  3. 3.Institute of PolymersBulgarian Academy of SciencesSofiaBulgaria

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