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Low dose computerized tomography examinations of coronary occlusive disease

  • Research Article
  • Published:
Central European Journal of Biology

Abstract

Background: The aim of this study was to present an original technique of low-dose coronary computerized tomographyangiography (CCTA) for the evaluation and early diagnosis of coronary occlusive disease (COD) and to compare from this technique of CCTA with those resulting from the latest conventional angiography and multidetector computerized tomography units. Methodology: The study included 820 CCTA exams of patients with COD (average age 61 +/− 7 years), with a follow-up exam in 204 male (39%) and 62 female (20%) patients with hemodynamically insignificant coronary occlusion. Exams were performed using a 64-slice computerized tomography (CT) unit using electrocardiography (ECG)-triggering and individual settings (voltage of the x-ray tube and effective tube-current) based on each patient’s body mass index. Exponential dose for each exam was defined. Results:There was a statistically significant progression in the number of patients in whom occlusion of one of 3 coronary arteries occurred in hemodynamically significant occlusive disease (occlusion of more than 50% of lumen) — 60 of 204 males and 12 of 62 females (p<0.0001 and p<0.001). The mid-effective radiation dose during CCTA exams was 1.9+/-0.7mSv (range of 0.9 to 3.9 mSv). Conclusion: Prospective ECG-triggering allowed for low-dose CCTA exams while still enabling high diagnostic accuracy in evaluating patients with COD. The technique used in this study resulted in 2 times less the exponential dose than conventional angiography.

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Authors and Affiliations

  1. Clinical center of Serbia, Center of Radiology, Belgrade, Serbia

    Ana Mladenovic & Zeljko Markovic

  2. School of Medicine, University of Belgrade, Belgrade, Serbia

    Ana Mladenovic & Zeljko Markovic

  3. Department of Radiation Oncology and Diagnostics, Institute of Oncology and Radiology of Serbia, Belgrade, Serbia

    Sandra Radenković

  4. Clinical center of Serbia, Cardiology Clinic, Belgrade, Serbia

    Bojana Orbovic

  5. Clinical Hospital “Bezanijska Kosa”, Belgrade, Serbia

    Vladimir Mirčetić & Goran Tomašek

Authors
  1. Ana Mladenovic
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  2. Zeljko Markovic
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  3. Sandra Radenković
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  4. Bojana Orbovic
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  5. Vladimir Mirčetić
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  6. Goran Tomašek
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Correspondence to Zeljko Markovic.

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Mladenovic, A., Markovic, Z., Radenković, S. et al. Low dose computerized tomography examinations of coronary occlusive disease. cent.eur.j.biol. 9, 967–972 (2014). https://doi.org/10.2478/s11535-014-0327-9

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  • DOI: https://doi.org/10.2478/s11535-014-0327-9

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