Skip to main content
SpringerLink
Log in

Efficacy and Safety of Treatment of Hypertensive Patients with Fixed Combination Perindopril/Indapamide Up to 10/2.5mg

Results of the FALCO FORTE Programme

  • Origial Research Article
  • Published:
High Blood Pressure & Cardiovascular Prevention Aims and scope Submit manuscript

Abstract

Background: The objective of the FALCOFORTE programme was to demonstrate the efficacy and safety of 3 months of therapy with the fixed combination perindopril/indapamide in hypertensive patients in everyday medical practice.

Design and methods: Patients with blood pressure >140/90mmHgor with blood pressure >130/85mmHg and three or more risk factors were prescribed perindopril/indapamide 2.5/0.625mg or 5/1.25 mg. Dosage could be increased to 10/2.5mg at any time during the study.

Results: Of the 2327 patients included, 69% of patients had been unsuccessfully treated with other antihypertensives, 4.6% had not tolerated previous antihypertensive treatments, and 26.8% were newly diagnosed hypertensive patients. Roughly half the cohort was at high or very high cardiovascular risk. After 3 months of therapy, systolic blood pressure decreased from 156.9 ± 13.7 to 132.3 ± 10.6mmHg (p < 0.0001) and diastolic blood pressure from 94.9 ± 8.2 to 81.3 ± 6.3 mmHg (p < 0.0001). Target blood pressure was reached by 87.1% of patients. Similar changes from baseline were observed in patients with diabetes mellitus, metabolic syndrome or left ventricular hypertrophy (p < 0.0001). When blood pressure decreases were analysed by dose, changes from baseline increased with increasing doses. Perindopril/indapamide was well tolerated with no significant changes in laboratory parameters being observed. Quality of life improved significantly.

Conclusions: Therapy with fixed combination perindopril/indapamide was effective and well tolerated in a wide range of patients.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Table I
Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

References

  1. Sninčák M, Balažovjech I, Macháčová E, et al. Epidemiológia artériovej hypertenzie na Slovensku. Intern Med 2006; 6: 3–26

    Google Scholar 

  2. Kannel WB. Blood pressure as a cardiovascular risk factor: prevention and treatment. JAMA 1996 May 22-29; 275(20): 1571–6

    Article  PubMed  CAS  Google Scholar 

  3. Assmann G, Schulte H. The Prospective Cardiovascular Munster (PROCAM) study: prevalence of hyperlipidemia in persons with hypertension and/or diabetes mellitus and the relationship to coronary heart disease. Am Heart J 1988 Dec; 116(6 Pt 2): 1713–24

    Article  PubMed  CAS  Google Scholar 

  4. Lloyd-Jones DM, Evans JC, Larson MG, et al. Treatment and control of hypertension in the community: a prospective analysis. Hypertension 2002 Nov; 40(5): 640–6

    Article  PubMed  CAS  Google Scholar 

  5. Chobanian AV, Bakris GL, Black HR, et al. The seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report. JAMA 2003 May 21; 289(19): 2560–72

    Article  PubMed  CAS  Google Scholar 

  6. Pella D, Fedacko J, Rybar R, et al. The reduction of total cardiovascular risk: results of the STRONG DUET study [abstract]. Eur J Cardiovasc Prev Rehab 2009; 16Suppl. 1: S105

    Google Scholar 

  7. Pella D. Cardiovascular risk stratification and evidence based medicine hypertension treatment: results of the scientific programme FALCO. Intern Med 2009; 9(1): 39–46

    Google Scholar 

  8. Cherry DK, Woodwell DA. National Ambulatory Medical Care Survey: 2000 summary. Adv Data 2002 Jun 5; 328: 1–32

    PubMed  Google Scholar 

  9. Mancia G, Grassi G. Systolic and diastolic blood pressure control in antihypertensive drug trials. J Hypertens 2002 Aug; 20(8): 1461–4

    Article  PubMed  CAS  Google Scholar 

  10. Basile J. Blood pressure responder rates versus goal rates: which metric matters? Ther Adv Cardiovasc Dis 2009 Apr; 3(2): 157–74

    Article  PubMed  Google Scholar 

  11. Mancia G, De Backer G, Dominiczak A, et al. 2007 Guidelines for the Management of Arterial Hypertension: the Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). J Hypertens 2007 Jun; 25(6): 1105–87

    Article  PubMed  CAS  Google Scholar 

  12. Moser M, Cushman WC, Kaplan NM. Control of blood pressure: does it matter which agent you use? J Clin Hypertens (Greenwich) 2007 Dec; 9(12): 964–73

    Article  Google Scholar 

  13. Pella D. Effective systolic blood pressure control by fixed low-dose combination of antihypertensive drugs: results of the scientific programme PROGRESSIVE. Intern Med 2007; 7(4): 217–23

    Google Scholar 

  14. Beckett NS, Peters R, Fletcher AE, et al. Treatment of hypertension in patients 80 years of age or older. N Engl J Med 2008 May 1; 358(18): 1887–98

    Article  PubMed  CAS  Google Scholar 

  15. Kostis JB. Treating hypertension in the very old. N Engl J Med 2008 May 1; 358(18): 1958–60

    Article  PubMed  CAS  Google Scholar 

  16. PROGRESS Collaborative Group. Randomised trial of a perindopril-based blood-pressure-lowering regimen among 6,105 individuals with previous stroke or transient ischaemic attack. Lancet 2001 Sep 29; 358 (9287): 1033–41

  17. Furie KL, Kasner SE, Adams RJ, et al. Guidelines for the prevention of stroke in patients with stroke or transient ischemic attack: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke 2011 Jan; 42(1): 227–76

    Article  PubMed  Google Scholar 

  18. Nishioku T, Takata F, Yamauchi A, et al. Protective action of indapamide, a thiazide-like diuretic, on ischemia-induced injury and barrier dysfunction in mouse brain microvascular endothelial cells. J Pharmacol Sci 2007 Mar; 103(3): 323–7

    Article  PubMed  CAS  Google Scholar 

  19. Dahlöf B, Gosse P, Gueret P, et al. Perindopril/indapamide combination more effective than enalapril in reducing blood pressure and left ventricular mass: the PICXEL study. J Hypertens 2005 Nov; 23(11): 2063–70

    Article  PubMed  Google Scholar 

  20. Mogensen CE, Viberti G, Halimi S, et al. Effect of low-dose perindopril/indapamide on albuminuria in diabetes: preterax in albuminuria regression — PREMIER. Hypertension 2003 May; 41(5): 1063–71

    Article  PubMed  CAS  Google Scholar 

  21. Patel A, MacMahon S, Chalmers J, et al. Effects of a fixed combination of perindopril and indapamide on macrovascular and microvascular outcomes in patients with type 2 diabetes mellitus (the ADVANCE trial): a randomised controlled trial. Lancet 2007 Sep 8; 370(9590): 829–40

    Article  PubMed  CAS  Google Scholar 

  22. Mancia G, Grassi G. Protection of patients with diabetes, with or without hypertension: implications of ADVANCE for clinical practice. J Hypertens Suppl 2009 May; 27(1): S19–23

    Article  PubMed  CAS  Google Scholar 

Download references

Acknowledgements

This study was supported by a research grant from SERVIER. The author has no conflicts of interest to declare. The author would like to thank to all the physicians who participated in this study and Hélène Dassule, PhD, for her editorial support.

Author information

Authors and Affiliations

  1. 3rd Department of Medicine, Centre of Excellency for Atherosclerosis Research, Medical Faculty PJ Safarik University and Louis Pasteur Hospital, Trieda SNP 1, 04190, Kosice, Slovakia, Europe

    Daniel Pella MD, PhD (Head)

Authors
  1. Daniel Pella MD, PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Daniel Pella MD, PhD.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Pella, D. Efficacy and Safety of Treatment of Hypertensive Patients with Fixed Combination Perindopril/Indapamide Up to 10/2.5mg. High Blood Press Cardiovasc Prev 18, 107–113 (2011). https://doi.org/10.2165/11593520-000000000-00000

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.2165/11593520-000000000-00000

Keywords

Search

Navigation