A 49-year-old man developed disseminated allergic contact dermatitis following exposure to neomycin- and geraniol-containing Blastoestimulina cream.
The man, who had a history of stasis dermatitis and atopy, presented with a 1-month history of a venous ulcer on the dorsum of his right toe. He started receiving topical Blastoestimulina cream, which contained neomycin and geraniol [dose not stated], and povidone iodine [Betadine] once daily. After 3 weeks, he developed a severe pruritic eczematous eruption localised around the ulcer. The eruption then spread to his upper limbs, arms and trunk.
Blastoestimulina and povidone iodine were discontinued and the man received oral antihistamines and systemic corticosteroids. His lesions disappeared in few days.
The man underwent patch test with Blastoestimulina cream, Betadine, the Spanish standard series and the fragrance mix. Strong positive reactions were observed on days 2 and 4 with Blastoestimulina, fragrance mix, nickel, cobalt chloride, potassium dichromate, geraniol, Bulgarian rose oil, geranium oil bourbon and geranium essence. The ingredients of Blastoestimulina were then patch tested, which showed positive reactions to neomycin, geraniol and lavender essence on days 2, 4 and 7. He was diagnosed with disseminated allergic contact dermatitis due to Blastoestimulina.Author Comment“In our case, the patient had multiple contact allergies to neomycin and to Bulgarian rose oil, geranium oil bourbon, geranium essence, and lavender (all of which contain geraniol).”
Topical - adverse reactions - drug-induced - Neomycin - Allergic-contact-dermatitis - Geraniol
REFERENCE
Juarez A, Goiriz R, Sanchez-Perez J, Garcia-Diez A.Disseminated allergic contact dermatitis after exposure to a topical medication containing geraniol. Dermatitis 19: 163, No. 3, May-Jun 2008 - Spain
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Geraniol/neomycin. React. Wkly. 1217, 16 (2008). https://doi.org/10.2165/00128415-200812170-00050
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DOI: https://doi.org/10.2165/00128415-200812170-00050