Novel local delivery strategies for preventing restenosis

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Local delivery of biologically active agents is a promising approach to preventing restenosis, according to data presented at the 17th Congress of the European Society of Cardiology [ Amsterdam, The Netherlands; August 1995 ]. US researchers aim to improve upon existing local delivery techniques by using biodegradable polymeric nanoparticles as a carrier for drugs which prevent neointimal proliferation. Other researchers have developed a fibrin adhesive capable of attaching endothelial cells to damaged arterial walls. Findings from preclinical studies with these strategies and their potential for clinical application were discussed at the meeting.