Inpharma Weekly

, Volume 930, Issue 1, pp 20–22 | Cite as

What can we learn from PROFILE and FIRST?

  • Rosie Stather
Newsletter Article


Over the last 20 years a single principle has guided the development of new drugs for chronic heart failure - they need to produce favourable haemodynamic effects either by enhancing cardiac contractility or by reducing wall stress. Two drugs showing such promise were flosequinan and epoprostenol. However, following favourable results in short-term trials, long-term trials for both drugs had to be terminated prematurely, within 6 weeks of each other, due to unacceptably high mortality in the treatment groups. Why did this happen? The results of both trials and the lessons that can be learnt from them were discussed at the American College of Cardiology 43rd Annual Scientific Session, held in Atlanta, Georgia, US, March 13-17th.


Chronic Heart Failure Haemodynamic Effect Cardiac Contractility Epoprostenol Neurohormonal Activation 
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© Adis International Ltd 1994

Authors and Affiliations

  • Rosie Stather

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