American Journal of Clinical Dermatology

, Volume 9, Issue 4, pp 267–270 | Cite as

Acute Kidney Injury in a Patient with Melanuria, Diffuse Melanosis, and Metastatic Malignant Melanoma

  • Thilo Gambichler
  • Markus Stücker
  • Katja Kerner
  • Stefan Weiner
  • Rüdiger Waldherr
  • Peter Altmeyer
  • Alexander Kreuter
Case Report Acute Kidney Injury Secondary to Melanuria


Diffuse melanosis with melanuria is a rare complication of metastatic malignant melanoma that is associated with a very poor prognosis. Acute kidney injury secondary to melanuria has not been reported previously. We describe a patient with malignant melanoma, diffuse melanosis, and melanuria who developed acute kidney injury that was clinically indicated by an increase in urinary excreted metabolites in the serum. Histopathologic examination of kidney tissue revealed damage to tubules associated with disseminated intra-tubular melanin deposits. Diffuse melanosis with melanuria may lead to morphologic and functional kidney changes and warrants careful monitoring of kidney function in affected malignant melanoma patients.


Hepatocyte Growth Factor Acute Kidney Injury Metastatic Malignant Melanoma Dipyrone Melanin Pigment 
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No sources of funding were used to assist in the preparation of this case report. The authors have no conflicts of interest that are directly relevant to the content of this case report.


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Copyright information

© Adis Data Information BV. 2008

Authors and Affiliations

  • Thilo Gambichler
    • 1
  • Markus Stücker
    • 1
  • Katja Kerner
    • 1
  • Stefan Weiner
    • 2
  • Rüdiger Waldherr
    • 3
  • Peter Altmeyer
    • 1
  • Alexander Kreuter
    • 1
  1. 1.Department of DermatologyRuhr-University BochumBochumGermany
  2. 2.Center for Dialysis, Nephrology, and Rheumatology, II Medical DepartmentTrierGermany
  3. 3.Private Practice for Pathology and CytologyHeidelbergGermany

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