American Journal of Clinical Dermatology

, Volume 4, Issue 11, pp 799–802 | Cite as

Cutaneous Psammomatous Melanotic Schwannoma

Non-Recurrence with Surgical Excision
  • Nadine Claessens
  • Olivier Heymans
  • Jorge E. Arrese
  • Roy Garcia
  • Bert Oelbrandt
  • Gérald E. Piérard
Case Reports


Background: Melanotic schwannoma is a pigmented nerve tumor that may be located in the skin and express local aggressivity. This tumor may occur singly. It may also be part of the Carney complex which consists of various, but specific, tumors.

Objective: We report two cases of subcutaneous melanotic schwannoma localized on the trunk in two men aged 37 and 45 years.

Methods: Conventional histology and immunohistochemistry were performed.

Results: One melanotic schwannoma was associated with a cutaneous atypical myxoma and multiple melanocytic lesions, all being part of the Carney complex. The other case had no associated signs. In both cases, the melanotic schwannoma was completely excised and did not recur.

Conclusion: Melanotic schwannoma is rare and curable by surgery. It must not be confused with malignant melanoma and other pigmented neoplasms. The Carney complex should be carefully ruled out.


Schwann Cell S100 Protein Neurofibroma Factor XIIIa Cardiac Myxoma 
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No sources of funding were used to assist in the preparation of this manuscript. The authors have no conflicts of interest that are directly relevant to the content of this manuscript.


  1. 1.
    Font RL, Truong LD. Melanotic schwannoma of soft tissues. Am J Surg Pathol 1984; 8: 129–38PubMedCrossRefGoogle Scholar
  2. 2.
    Killeen RM, Davy CL, Bauserman SC. Melanotic schwannoma. Cancer 1988; 62: 174–83PubMedCrossRefGoogle Scholar
  3. 3.
    Carney JA. Psammomatous melanotic schwannoma. Am J Surg Pathol 1990; 14: 206–22PubMedCrossRefGoogle Scholar
  4. 4.
    Bouziani A, Kammoun N, Zidi B, et al. Le schwannome mélanotique: une observation avec revue de la littérature. Arch Anat Cytol Pathol 1994; 2: 46–53Google Scholar
  5. 5.
    Burns K, Silva FG, Forde KA, et al. Primary melanotic schwannoma of the stomach: evidence of dual melanocytic and schwannoma differentiation in extra-axial site in a patient without neurofibromatosis. Cancer 1983; 52: 1432–41PubMedCrossRefGoogle Scholar
  6. 6.
    Erlandson RA. Melanotic schwannoma of spinal nerve origin. Ultrastruct Pathol 1985; 9: 123–9PubMedCrossRefGoogle Scholar
  7. 7.
    Noubari BA, Chiaramonte I, Magro G, et al. Spinal malignant melanotic schwannoma. J Neurosurg Sci 1998; 42: 245–9PubMedGoogle Scholar
  8. 8.
    Carney JA, Gordon H, Carpenter PC, et al. The complex of myxomas, spotty pigmentation and endocrine over-activity. Medicine 1985; 64: 270–82PubMedCrossRefGoogle Scholar
  9. 9.
    Carney JA, Hruska LS, Beauchamps GD, et al. Dominant inheritance of the complex of myxomas, spotty pigmentation, and endocrine overactivity. Mayo Clin Proc 1986; 61: 165–72PubMedGoogle Scholar
  10. 10.
    Danoff A, Jormark S, Lorber D, et al. Adrenocortical micronodular dysplasia, cardiac myxomas, lentigines, and spindle cell tumors. Arch Intern Med 1987; 147: 443–8PubMedCrossRefGoogle Scholar
  11. 11.
    Thornton CM, Handley J, Bingham EA, et al. Psammomatous melanotic schwannoma arising in the dermis in a patient with Carney’s complex. Histopathology 1992; 20: 71–3PubMedCrossRefGoogle Scholar
  12. 12.
    Utiger CA, Headington JT. Psammomatous melanotic schwannoma: a new cutaneous marker for Carney’s complex. Arch Dermatol 1993; 129: 202–4PubMedCrossRefGoogle Scholar
  13. 13.
    Carney JA, Ferreiro JA. The epithelioid blue nevus: a multicentric familial tumor with important associations, including cardiac myxoma and psammomatous melanotic schwannoma. Am J Surg Pathol 1996; 20: 259–72PubMedCrossRefGoogle Scholar
  14. 14.
    Monteagudo C, Ferrandez A, Gonzalez-Devesa M, et al. Psammomatous malignant melanoma arising in an intradermal naevus. Histopathology 2001; 39: 493–7PubMedCrossRefGoogle Scholar
  15. 15.
    Aso M, Hashimoto K, Eto H, et al. Expression of Schwann cell characteristics in pigmented nevus. Immunohistochemical study using monoclonal antibody to Schwann cell associated antigen. Cancer 1988; 62: 938–43PubMedCrossRefGoogle Scholar
  16. 16.
    Gray MH, Smoller BR, McNutt NS, et al. Immunohistochemical demonstration of factor XIIIa expression in neurofibromas. A practical means of differentiating these tumors from neurotized melanocytic nevi and schwannomas. Arch Dermatol 1990; 126: 472–6PubMedCrossRefGoogle Scholar

Copyright information

© Adis Data Information BV 2003

Authors and Affiliations

  • Nadine Claessens
    • 1
  • Olivier Heymans
    • 2
  • Jorge E. Arrese
    • 1
  • Roy Garcia
    • 1
    • 3
  • Bert Oelbrandt
    • 2
  • Gérald E. Piérard
    • 1
  1. 1.Department of DermatopathologyUniversity Hospital Sart TilmanLiègeBelgium
  2. 2.Department of Plastic and Reconstructive SurgeryUniversity Medical Center Sart TilmanLiègeBelgium
  3. 3.Department of DermatologyHospital Nacional Sur-este EssaludCuscoPeru

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