Drug-Induced Nail Abnormalities
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This article reviews the different nail symptoms produced by drugs. Drug-induced nail abnormalities may result from toxicity to the matrix, the nail bed or the periungual tissues. The most common symptoms include Beau’s lines/onychomadesis, melanonychia, onycholysis, and periungual pyogenic granulomas. Nail changes usually affect several nails and in most cases are asymptomatic. Drugs that most frequently produce nail abnormalities include retinoids, indinavir, and cancer chemotherapeutic agents. In this article, we also include nail adverse effects as a result of radiotherapy since they are commonly observed in clinical practice.
KeywordsRetinoid Indinavir Nail Plate Pyogenic Granuloma Paronychia
No sources of funding were used to assist in the preparation of this manuscript. The authors have no conflicts of interest that are directly relevant to the content of this manuscript.
- 4.Daniel III C.R., Scher R.K. Nail changes secondary to systemic drugs and ingestans. In: Sher R.K., Daniel III C.R. Nails: therapy, diagnosis, surgery. Philadelphia (PA): WB Saunders Company, 1997: 251–275Google Scholar
- 7.Vanhooteghem O., Richert B., Vindevoghel A., et al. Subungual abscess: an ungual side-effect related to docetaxel therapy. Br J Dermatol 2000 Aug; 43 (2): 445–473Google Scholar
- 9.Varotti C., Ghetti E., Piraccini B.M., et al. Subungual hematoma in a patient treated with an oral anticoagulant (warfarin sodium). Eur J Dermatol 1997; 7 (5): 395–396Google Scholar