Drugs in R & D

, Volume 1, Issue 6, pp 463–469 | Cite as

Lipid-Altering Drugs in Development

  • Harold E. Bays
  • Carlos A. Dujovne
Section 2: Lipid Disorder Leading Article

Abstract

Although currently available lipid lowering therapies are effective and well tolerated, the search continues for additional treatments with even better efficacy and tolerability profiles. As well as refinements to existing strategies (new HMG-CoA reductase inhibitors, fibrates and combination therapies) new avenues are being explored. These include inhibitors of enzymes other thanHMG-CoA reductase involved in cholesterol regulation and drugs which affect absorption of lipids from the gastrointestinal tract. In the case of the latter, it has been shown that the new antiobesity treatment orlistat can favourably affect the blood lipid profile. In line with an increasing emphasis on improving high density lipoprotein-cholesterol (HDL-C) levels, the potential therapeutic roles of niacin and drugs which inhibit enzymes involved in the metabolism of HDL-C are also being researched.

Keywords

Adis International Limited Orlistat Cholesteryl Ester Transfer Protein Sibutramine Microsomal Triglyceride Transfer Protein 

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Copyright information

© Adis International Limited 1999

Authors and Affiliations

  • Harold E. Bays
    • 1
  • Carlos A. Dujovne
    • 2
  1. 1.Louisville Metabolic and Atherosclerosis Research CenterNortons Audubon HospitalLouisvilleUSA
  2. 2.Mid-Continent Clinical Trials - Radiant Research, Lipid, Heart Disease, Stroke and Weight Control Metabolic Diseases ClinicsKansas Foundation for Clinical PharmacologyOverland ParkUSA

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