Drugs in R & D

, Volume 1, Issue 1, pp 92–94 | Cite as

MEDI 500

Anti-TCR-αβ Monoclonal Antibody T10B9, G 022, T-10B9, T10B9, T10B9 Monoclonal Antibody, T10B9.1A31, T12A10
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Keywords

Acute GVHD Transplant Rejection Heart Lung Transplant Renal Allograft Rejection Heart Transplant Rejection 

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References

  1. 1.
    Lucas BA, Waid TH, Thompson JS, et al. Comparison of T10B9.1A-31 and OKT3 in treating acute renal allograft rejection. Trans Proc 1993 Feb; 25 Pt 1: 54–5Google Scholar
  2. 2.
    Waid TH, Lucas BA, Thompson JS, et al. Treatment of renal allograft rejection with T10B9.1A31 or OKT3: final analysis of a phase II clinical trial. Transplantation 1997 Jul 27; 64: 274–81PubMedCrossRefGoogle Scholar
  3. 3.
    Thompson JS, Brown SA, Barve S. Mechanism of immunosuppression by the murine IgM anti-T cell monoclonal antibody (mAb) T10B9.1A-31 (T10B9). J Cell Biochem 1995; Suppl. 21A: 179Google Scholar
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    Thompson JS, Brown SA, Barve S. T10B9.1A-31: a study of biofunctions important in the induction of tolerance. International Congress on New Immunosuppressive Drugs; 1995 Aug 27: 40Google Scholar
  5. 5.
    Brown SA, Lucas BA, Waid TH, et al. T10B9 (MEDI-500) mediated immunosuppression: studies on the mechanism of action. Clin Transplant 1996 Dec; 10 Pt 2: 607–13PubMedGoogle Scholar
  6. 6.
    Henslee-Downey PJ, Parrish RS, Macdonald JS, et al. Combined in vitro and in vivo T lymphocyte depletion for the control of graft-versus-host disease following haploidentical marrow transplant. Transplantation 1996 Mar 15; 61: 738–45PubMedCrossRefGoogle Scholar
  7. 7.
    Waid TH, Thompson JS, McKeown JW, et al. Induction immunotherapy in heart transplantation with T10B9.1A-31: a phase I study. J Heart Lung Transplant 1997 Sep; 16: 913–16PubMedGoogle Scholar
  8. 8.
    Waid TH, Sekela ME, Thompson JS, et al. Induction therapy with T10B9.1A31 is equivalent to OKT3 in cardiac allograft recipients. J Heart Lung Transplant 1995 Jan–Feb; 14 Pt 2: 50Google Scholar

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© Adis International Limited 1999

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