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BioDrugs

, Volume 17, Supplement 1, pp 15–18 | Cite as

Rapid Protection against Hepatitis A and B Using an Accelerated Vaccination Schedule

Comparison of Combined Vaccine, Twinrix®, with Separate Vaccines
  • Hans D. Nothdurft
  • Manfred Dietrich
  • Jane N. Zuckerman
  • Jürgen Knobloch
  • Peter Kern
  • Roland Sänger
Short Communication

Keywords

Seroconversion Rate Seroprotection Rate Monovalent Vaccine GlaxoSmithKline Biological Havrix 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgements

The authors have provided no information on sources of funding or on conflicts of interest directly relevant to the content of this short communication.

References

  1. 1.
    Nothdurft HD, Dietrich M, Zuckerman JN, et al. A new accelerated vaccination schedule for rapid protection against hepatitis A and B. Vaccine 2002; 20(7-8): 1157–62PubMedCrossRefGoogle Scholar
  2. 2.
    Löscher T, Keystone JS, Steffen R. Vaccination of travellers against hepatitis A and B. J Travel Med 1999; 6: 107–14PubMedCrossRefGoogle Scholar
  3. 3.
    Van Damme P, Cramm M, Van Gompel A, et al. Analysis of travellers profile in Belgium [abstract 371]. Proceedings of the 3rd Conference on International Travel Medicine; 1993 Apr 25–29; Paris, France: 267Google Scholar
  4. 4.
    Bruguera M, Bayas JM, Vilella A, et al. Immunogenicity and reactogenicity of a combined hepatitis A and B vaccine in young adults. Vaccine 1996; 14(15): 1407–11PubMedCrossRefGoogle Scholar
  5. 5.
    Leroux-Roels G, Moreau E, Desombre I, et al. Safety and immunogenicity of a combined hepatitis A and B vaccine in young healthy adults. Scand J Gastroenterol 1996; 31: 1027–31PubMedCrossRefGoogle Scholar
  6. 6.
    Ruetter J, Bart PA, Francioli P, et al. Production of antibody to hepatitis A virus and hepatitis B surface antigen measured after combined hepatitisA/hepatitis B vaccination in 242 adult volunteers. J Viral Hepat 1998; 5(3): 205–11CrossRefGoogle Scholar
  7. 7.
    Thompson SC, Norris M. Immunogenicity and reactogenicity of a combined hepatitis A and B vaccine in adolescents. Int J Infect Dis 1998; 2: 193–6PubMedCrossRefGoogle Scholar
  8. 8.
    Van Damme P, Lievens M, Stoffel M, et al. Rapid seroconversion rates after first dose of an inactivated hepatitis A vaccine (Havrix 1440™) [abstract]: results of a retrospective analysis. In: Travel & Epidemics. 3rd European Conference on Travel Medicine; 2002 May 15–18; Florence, Italy: 210Google Scholar
  9. 9.
    Iwarson S, Lindh M, Widerström L. Excellent booster response 4–6 y after a single primary dose of an inactivated hepatitis A vaccine. Scand J Infect Dis 2002; 34: 110–1PubMedCrossRefGoogle Scholar
  10. 10.
    Bock HL, Loscher T, Scheiermann N, et al. Accelerated schedule for Hepatitis B immunization. J Travel Med 1995; 2: 213–7PubMedCrossRefGoogle Scholar
  11. 11.
    Thoelen S, Van Damme P, Leentvaar-Kuypers A, et al. The first combined vaccine against hepatitis A and B: an overview. Vaccine 1999; 17(13-14): 1657–62PubMedCrossRefGoogle Scholar
  12. 12.
    Bock HL, Kruppenbacher JP, Bienzle U, et al. Does the concurrent administration of an inactivated hepatitis A vaccine influence the immune response to other travelers vaccines? J Travel Med 2000; 7: 74–8PubMedCrossRefGoogle Scholar
  13. 13.
    Joines RW, Blatter M, Abraham B, et al. A prospective, randomized, comparative US trial of a combination hepatitis A and B vaccine (Twinrix) with corresponding monovalent vaccines (Havrix and Engerix-B) in adults. Vaccine 2001; 19: 4710–9PubMedCrossRefGoogle Scholar
  14. 14.
    Wagstaff AJ, Balfour JA. Combination hepatitis A and B vaccine. BioDrugs 1997; 8: 235–9PubMedCrossRefGoogle Scholar
  15. 15.
    Burgess MA, Rodger AJ, Waite SA, et al. Comparative immunogenicity and safety of two dosing schedules of a combined hepatitis A and B vaccine in healthy adolescent volunteers: an open, randomised study. Vaccine 2001; 19: 4835–41PubMedCrossRefGoogle Scholar
  16. 16.
    Van Der Wielen M, Van Damme P, Collard F. A two dose schedule for combined hepatitis A and hepatitis B vaccination in children ages one to eleven years. Pediatr Infect Dis J 2000; 19: 848–53CrossRefGoogle Scholar
  17. 17.
    Ramonet M, da Silveira TR, Lisker-Melman M, et al. A two-dose combined vaccine against hepatitis A and hepatitis B in healthy children and adolescents compared to the corresponding monovalent vaccines. Arch Med Res 2002; 33: 67–73PubMedCrossRefGoogle Scholar
  18. 18.
    Bosnak M, Dikici B, Bosnak V, et al. Accelerated hepatitis B vaccination schedule in childhood. Pediatr Int 2002; 44: 663–5PubMedCrossRefGoogle Scholar

Copyright information

© Adis Data Information BV 2003

Authors and Affiliations

  • Hans D. Nothdurft
    • 1
  • Manfred Dietrich
    • 2
  • Jane N. Zuckerman
    • 3
  • Jürgen Knobloch
    • 4
  • Peter Kern
    • 5
  • Roland Sänger
    • 6
  1. 1.Department of Infectious Diseases and Tropical MedicineLudwig-Maximilians UniversityLeopoldstr. 5Germany
  2. 2.Department of MedicineBernhard-Nocht Institute for Tropical MedicineHamburgGermany
  3. 3.Royal Free and University College Medical School, University College LondonLondonUK
  4. 4.Institute of Tropical Medicine, University HospitalTübingenGermany
  5. 5.University Hospital and Medical CenterUlmGermany
  6. 6.GlaxoSmithKline GmbH & Co. KGMunichGermany

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