BioDrugs

, Volume 15, Issue 11, pp 729–743 | Cite as

Pathophysiological Role of Leukotrienes in Dermatological Diseases

Potential Therapeutic Implications
Review Article

Abstract

In vitro and in vivo data have demonstrated that leukotrienes play a key role not only in allergic airway diseases but also in inflammatory reactions of the skin. Antileukotriene drugs, i.e. leukotriene receptor antagonists and synthesis inhibitors, are a new class of anti-inflammatory drugs that have shown clinical efficacy in the management of asthma, allergic rhinitis and inflammatory bowel disease. To address the question of the validity and applicability of published evidence of the use of antileukotriene drugs in dermatological diseases, we reviewed data concerning the pathophysiological effect of leukotrienes in the skin and in skin diseases, and the experience with antileukotriene treatment that has been published.

In vivo and in vitro data suggest that antileukotriene treatment may have efficacy in atopic dermatitis, different types of urticaria or psoriasis and other skin diseases such as bullous skin diseases, collagenoses, Sjogren-Larsson syndrome or Kawasaki disease. Nevertheless, published evidence is very limited and before any conclusions can be drawn, additional basic research needs to be performed with regard to the role of different leukotrienes and leukotriene receptors in skin diseases.

On the basis of these data, randomised and placebo-controlled clinical trials with leukotriene antagonists and synthesis inhibitors should be performed. Moreover, future studies investigating the additive benefit of antileukotriene drugs are warranted, e.g. in combination with antihistamines, corticosteroids or other antiinflammatory drugs.

Keywords

Psoriasis Atopic Dermatitis Kawasaki Disease Montelukast LTB4 

Notes

Acknowledgements

The authors received no funding for the preparation of this manuscript and have no conflicts of interest with any relevant pharmaceutical companies.

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Copyright information

© Adis International Limited 2001

Authors and Affiliations

  1. 1.Department of Dermatology and AllergologyHannover Medical UniversityHannoverGermany

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