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BioDrugs

, Volume 15, Issue 6, pp 413–418 | Cite as

Antibody Responses of Healthy Infants to Concurrent Administration of a Bivalent Haemophilus influenzae Type b-Hepatitis B Vaccine with Diphtheria-Tetanus-Pertussis, Polio and Measles-Mumps-Rubella Vaccines

  • David J. WestEmail author
  • Gerard P. Rabalais
  • Barbara Watson
  • Harry L. Keyserling
  • Holly Matthews
  • Teresa M. Hesley
Original Research Article

Abstract

Objective: To confirm that children given a bivalent Haemophilus influenzae type b-hepatitis B vaccine (bivalent Hib-HB vaccine; COMVAX™) concurrently with priming doses of diphtheria-tetanus-pertussis vaccine (DTP), a booster dose of diphtheria-tetanus-acellular pertussis vaccine (DTaP), inactivated or oral polio vaccine (IPV or OPV) and measles-mumps-rubella vaccine (M-M-R®II) have satisfactory antibody responses to all antigens.

Design: 126 healthy 2-month-old infants were scheduled to receive bivalent Hib-HB vaccine concurrently with DTP (2 and 4 months of age), OPV or IPV (random allocation to OPV or IPV at 2 months of age; OPV at 4 and 14 to 15 months of age), DTaP and M-M-R®n (14 to 15 months of age). A response was judged ‘adequate’ if the lower bound of the 95% confidence interval on the proportion of vaccinees having a critical antibody level was <10 percentage points below prediction.

Result: Antibodies to hepatitis B virus surface antigen, H. influenzae polysaccharide, diphtheria toxin, tetanus toxin, pertussis agglutinogens, pertussis toxin (as measured by enzyme immunoassay but not by Chinese hamster ovary cell assay), pertussis filamentous haemagglutinin after a booster dose of DTaP, poliovirus type 2, measles virus, and mumps virus all equalled or exceeded expected levels. Antibodies to rubella virus and pertussis filamentous haemagglutinin (after priming doses of DTP) fell slightly, and in the case of rubella significantly, below predicted levels. Antibodies to poliovirus types 1 and 3 were also below expectation after 2 doses of polio vaccine but were adequate following a third dose of vaccine.

Conclusion: Concurrent administration of bivalent Hib-HB vaccine with priming doses of DTP, a booster dose of DTaP, OPV, IPV, or M-M-R®II was well tolerated and, with the possible exception of rubella, did not substantially impair the antibody response to any antigen.

Keywords

Pertussis Booster Dose Pertussis Vaccine Rubella Virus Priming Dose 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgements

This study was supported financially by the Merck Research Laboratories.

References

  1. 1.
    Kane MA. Hepatitis B control through immunization. In: Rizzetto M, Purcell RH, Gerin JL, et al., editors. Viral hepatitis and liver disease. Turin: Edizioni Minerva Medica 1997: 638-42Google Scholar
  2. 2.
    World Health Organization. WHO position paper on Haemophilus influenzae type b conjugate vaccines. Available at: http://www.who.int/vaccines-diseases/hibpospaper.htm [Accessed 2000 Dec 28]
  3. 3.
    Centers for Disease Control. Haemophilus b conjugate vaccines for the prevention of Haemophilus influenzae type b disease among infants and children two months of age and older: recommendations of the Immunization Practices Advisory Committee (ACIP). MMWR Morbid Mortal Wkly Rep 1991; 40(RR-l): 1–7Google Scholar
  4. 4.
    Centers for Disease Control. Hepatitis B virus: a comprehensive strategy for eliminating transmission in the United States through universal childhood vaccination: recommendations of the Immunization Practices Advisory Committee (ACIP). MMWR Morbid Mortal Wkly Rep 1991; 40(RR-13): 1–25Google Scholar
  5. 5.
    West DJ, Hesley TM, Jonas LC, et al. Safety and immunogenicity of a bivalent Haemophilus influenzae type b/hepatitis B vaccine in healthy infants. Pediatr Infect Dis J 1997; 16: 593–9PubMedCrossRefGoogle Scholar
  6. 6.
    Vella PP, Staub JM, Armstrong J, et al. Immunogenicity of a new Haemophilus influenza type b conjugate vaccine (meningococcal protein conjugate) (PedvaxHIB®). Pediatrics 1990; 85 (Suppl.): 668–75PubMedGoogle Scholar
  7. 7.
    Shehab ZM, Brunell PA, Cobb E. Epidemiological standardization of a test for susceptibility to mumps. J Infect Dis 1984; 149: 810–2PubMedCrossRefGoogle Scholar
  8. 8.
    Salk JE, Youngner JS, Ward EN. Use of color change of phenol red as the indicator in titrating poliomyelitis virus or its antibody in a tissue-culture system. Am J Hyg 1954; 60: 214–30PubMedGoogle Scholar
  9. 9.
    Albrecht P, van Steenis G, van Wezel AL, et al. Standardization of poliovirus neutralizing antibody tests. Rev Infect Dis 1984; 6Suppl. 2: S540–4PubMedCrossRefGoogle Scholar
  10. 10.
    Miyamura K, Tajiri E, Ito A, et al. Micro cell culture method for determination of diphtheria toxin and antitoxin titers using VERO cells. J Biol Stand 1974; 2: 203–9PubMedCrossRefGoogle Scholar
  11. 11.
    Manclark CR, Meade BD, Burstyn DG. Serological response to Bordetella pertussis. In: Rose NR, Friedman H, Fahey JL, editors. Manual of clinical laboratory immunology, 3rd edition. Washington, DC: American Society for Microbiology, 1986: 388–94Google Scholar
  12. 12.
    Gillenius P, Jäätmaa E, Askelof P, et al. The standardization of an assay for pertussis toxin and antitoxin in microplate culture of Chinese hamster ovary cells. J Biol Stand 1985; 13: 61–6PubMedCrossRefGoogle Scholar
  13. 13.
    West DJ, Boslego JW, Mendelman PM, et al. Concurrent administration of routine pediatric vaccines with COMVAX™ (Haemophilus b Conjugate [Meningococcal Protein Conjugate] and Hepatitis B [Recombinant] Vaccine). Pediatr Res 1997; 41(4 pt 2): 133ACrossRefGoogle Scholar

Copyright information

© Adis International Limited 2001

Authors and Affiliations

  • David J. West
    • 1
    Email author
  • Gerard P. Rabalais
    • 2
  • Barbara Watson
    • 3
  • Harry L. Keyserling
    • 4
  • Holly Matthews
    • 5
  • Teresa M. Hesley
    • 5
  1. 1.North WalesUSA
  2. 2.Pediatric Infectious DiseasesUniversity of LouisvilleLouisvilleUSA
  3. 3.Albert Einstein Healthcare NetworkPhiladelphiaUSA
  4. 4.Dept. of PediatricsEmory University School of MedicineAtlantaUSA
  5. 5.Merck & Co., Inc.Blue BellUSA

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