, Volume 13, Issue 4, pp 227–231 | Cite as

Melanoma Vaccines in Development

Looking to the Future
  • Reinhard Dummer
  • Frank O. Nestle
Leading Article


There is a body of evidence indicating that melanoma is an antigenic tumour. Since the efficacy of standard therapy in advanced stages of melanoma is rather poor, experimental immunotherapy aims to target this aggressive neoplasm. After the identification of several melanoma antigens, vaccination trials have been initiated in patients with metastatic disease using peptides, dendritic cells and gene therapy approaches including viral vectors or naked DNA. If the problems in inducing a constant and potent T cell response are solved, the stability of melanoma antigens and their presentation will decide whether these treatment approaches will reach significant relevance in daily clinical practice.


Melanoma Tumour Antigen Autologous Tumour Cell Melanoma Antigen Lymphatic Organ 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Grants from the Cancer League Zürich and the Swiss Cancer League to F.O. Nestle, and from the Swiss Science Foundation to R. Dummer (no. 31-55727.98), are gratefully acknowledged.


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Copyright information

© Adis International Limited 2000

Authors and Affiliations

  1. 1.Department of DermatologyUniversity HospitalZurichSwitzerland

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