BioDrugs

, Volume 10, Issue 2, pp 111–121 | Cite as

Potential of Anticomplement Therapy in Clinical Transplantation

  • Timothy J. Kroshus
  • R. Morton BolmanIII
  • Agustin P. Dalmasso
Review Article Immunological Disorders
  • 9 Downloads

Abstract

The activation of complement contributes to tissue damage in many ways. Prevention of complement activation in organ transplantation has largely centred on studies in xenotransplantation, where complement plays a key role in the pathogenesis of hyperacute rejection. Transgenic porcine organs expressing human regulators of complement activation in combination with soluble inhibitors as well as appropriate immunosuppression may be sufficient to alleviate the major immunological barriers that currently prevent the use of xenogeneic organs for human transplantation.

Keywords

Adis International Limited Complement Activation Membrane Attack Complex Complement Inhibitor Hyperacute Rejection 

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Copyright information

© Adis International Limited 1998

Authors and Affiliations

  • Timothy J. Kroshus
    • 1
  • R. Morton BolmanIII
    • 1
  • Agustin P. Dalmasso
    • 1
  1. 1.Departments of Surgery and Laboratory Medicine and PathologyUniversity of Minnesota and the Veterans Affairs Medical CenterMinneapolisUSA

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