BioDrugs

, Volume 9, Issue 6, pp 435–442 | Cite as

Recent Advances in Therapy of Sepsis

Focus on Recombinant Bactericidal/Permeability-Increasing Protein (BPI)
Leading Article

Summary

The inability to reduce the high mortality due to overwhelming bacterial infection and sepsis has prompted a search for new therapeutic agents. Among these may be a wide range of endogenous antibiotic polypeptides that are prominent components of effective antimicrobial host defences. One of these polypeptide antibiotics is the bactericidal/permeability-increasing protein (BPI), a protein of approximately 55kD which is present in human and other mammalian neutrophils. BPI is toxic for Gram-negative bacteria and binds to endotoxin, resulting in its clearance and neutralisation. Arecombinant 21kD N-terminal BPI fragment is at least as active as holo-BPI and protects both animals and humans against the effects of Gram-negative infections and their complications. Phase II/III clinical trials in fulminant paediatric meningococcaemia, haemorrhagic trauma, hepatectomy and severe peritoneal infections are in progress.

Keywords

Adis International Limited Lipopolysaccharide Binding Protein Curr Opin Immunol Amino Terminal Fragment Antimicrobial Polypeptide 

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Copyright information

© Adis International Limited 1998

Authors and Affiliations

  1. 1.Departments of Medicine and MicrobiologyNew York University School of MedicineNew YorkUSA

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