, Volume 8, Issue 1, pp 1–5 | Cite as

Prospects for T Cell Vaccination in Multiple Sclerosis

  • Robert Medaer
  • Piet Stinissen
  • Jingwu Zhang
  • Jef Raus
Leading Article


Accumulating evidence indicates that multiple sclerosis, a chronic inflammatory disease of the central nervous system, has an autoimmune origin. Since T cells reactive to myelin basic protein (MBP) are thought to play an important role in the pathogenesis of this disease, it was assumed that inactivation or depletion of this pathogenic T cell subset may have therapeutic effects in multiple sclerosis. We have recently reported that T cell vaccination, i.e. immunisation with attenuated autologous MBP-reactive T cell clones, leads to the depletion of the MBP-reactive T cells. Furthermore, this approach induced favourable clinical effects in the treated patients, encouraging further studies of T cell vaccination in multiple sclerosis.


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Copyright information

© Adis International Limited 1997

Authors and Affiliations

  • Robert Medaer
    • 1
  • Piet Stinissen
    • 1
  • Jingwu Zhang
    • 1
  • Jef Raus
    • 1
  1. 1.Dr L Willems-Instituut and Limburgs Universitair CentrumDiepenbeekBelgium

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