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Clinical Drug Investigation

, Volume 26, Issue 11, pp 629–638 | Cite as

Health-Economic Comparison of Paricalcitol, Calcitriol and Alfacalcidol for the Treatment of Secondary Hyperparathyroidism during Haemodialysis

  • Hubertus Rosery
  • Rito Bergemann
  • Steven E. Marx
  • Axel Boehnke
  • Joel Melnick
  • Raimund Sterz
  • Laura Williams
Review Article

Abstract

This study evaluated the health-economic consequences of use of intravenous paricalcitol (Zemplar®), oral calcitriol or oral and intravenous alfacalcidol for the treatment of patients with secondary hyperparathyroidism, focusing on a third-party payer perspective through inclusion of medication and hospital costs, survival rates and utilities. Cost values were based on German treatment recommendations and prices. Reference values for survival rates and utilities were based on the results of a MEDLINE search. The analysis showed a clear advantage for intravenous paricalcitol with respect to costs, effectiveness and utilities compared with treatment with oral calcitriol or intravenous alfacalcidol. Since the results were very cost sensitive with respect to selected diagnosis-related groups (DRGs) for kidney disease with dialysis, a sensitivity analysis was performed. This demonstrated first-order dominance of intravenous paricalcitol for a wide range of hospitalisation costs. In conclusion, this analysis suggested a clear benefit from the perspective of a third-party payer for intravenous paricalcitol compared with oral calcitriol and intravenous alfacalcidol in the treatment of patients with secondary hyperparathyroidism.

Keywords

Chronic Kidney Disease Haemodialysis Patient Utility Score Secondary Hyperparathyroidism Define Daily Dose 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgements

Compilation of this review was funded by Abbott prior to completion of the review, and funding was thus independent of the research results. Drs Marx, Melnick, Sterz and Williams and Mr Boehnke are employees of Abbott. Drs Rosery and Bergemann have no conflicts of interest that are directly relevant to the content of this review.

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Copyright information

© Adis Data Information BV 2006

Authors and Affiliations

  • Hubertus Rosery
    • 1
  • Rito Bergemann
    • 1
  • Steven E. Marx
    • 2
  • Axel Boehnke
    • 3
  • Joel Melnick
    • 2
  • Raimund Sterz
    • 3
  • Laura Williams
    • 2
  1. 1.Analytica International GmbH, German OfficeLoerrachGermany
  2. 2.Abbott LaboratoriesChicagoUSA
  3. 3.Abbott GmbH & Co. KGLudwigshafenGermany

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