Clinical Drug Investigation

, Volume 17, Issue 6, pp 467–473 | Cite as

Functional Effects of Controlled Physical Activity in Children and Young Adults Affected by Exercise-Induced Asthma Treated with Corticosteroids and β2-Agonists

  • M. Verini
  • A. Verrotti
  • R. Greco
  • F. Chiarelli
Clinical Pharmacodynamics


Objective: The aim of the study was to evaluate the influence and validity of a controlled physical exercise programme and two different premedications in preventing exercise-induced asthma in children and young adults.

Patients and Methods: A total of 42 children and young adults (20 male and 22 female) with exercise-induced asthma were studied. The physical exercise consisted of 10 minutes of warming-up exercises of mean intensity, 30 minutes of interval training, and 10 minutes of submaximum physical activity able to induce an increase in heart rate up to 160 to 180 beats/min, followed by 10 minutes of warm-down. Patients were divided into two groups according to their drug premedication: group A (21 patients): 100μg of beclomethasone + 200μg of salbutamol; group B (21 patients): 250μg of flunisolide + 10μg of procaterol.

Results: Pretreatment with controlled physical exercise produced a statistically significant (p < 0.005) increase in the respiratory function in these children and young adults for all groups. In particular, patients in group B who received flunisolide (250μg) + procaterol (10μg) showed an increase that was significantly greater (p < 0.000005) than that obtained after the bronchodilation test alone.

Conclusion: Our study demonstrated a beneficial effect of controlled physical exercise in children and young adults with exercise-induced asthma. This exercise significantly increased the effect of drug premedication.


Adis International Limited Salbutamol Force Vital Capacity Salmeterol Beclomethasone 
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Copyright information

© Adis International Limited 1999

Authors and Affiliations

  • M. Verini
    • 1
  • A. Verrotti
    • 1
  • R. Greco
    • 1
  • F. Chiarelli
    • 1
  1. 1.Department of Medicine, Section of PediatricsUniversity of ChietiItaly

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