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Clinical Drug Investigation

, Volume 17, Issue 6, pp 467–473 | Cite as

Functional Effects of Controlled Physical Activity in Children and Young Adults Affected by Exercise-Induced Asthma Treated with Corticosteroids and β2-Agonists

  • M. Verini
  • A. Verrotti
  • R. Greco
  • F. Chiarelli
Clinical Pharmacodynamics

Abstract

Objective: The aim of the study was to evaluate the influence and validity of a controlled physical exercise programme and two different premedications in preventing exercise-induced asthma in children and young adults.

Patients and Methods: A total of 42 children and young adults (20 male and 22 female) with exercise-induced asthma were studied. The physical exercise consisted of 10 minutes of warming-up exercises of mean intensity, 30 minutes of interval training, and 10 minutes of submaximum physical activity able to induce an increase in heart rate up to 160 to 180 beats/min, followed by 10 minutes of warm-down. Patients were divided into two groups according to their drug premedication: group A (21 patients): 100μg of beclomethasone + 200μg of salbutamol; group B (21 patients): 250μg of flunisolide + 10μg of procaterol.

Results: Pretreatment with controlled physical exercise produced a statistically significant (p < 0.005) increase in the respiratory function in these children and young adults for all groups. In particular, patients in group B who received flunisolide (250μg) + procaterol (10μg) showed an increase that was significantly greater (p < 0.000005) than that obtained after the bronchodilation test alone.

Conclusion: Our study demonstrated a beneficial effect of controlled physical exercise in children and young adults with exercise-induced asthma. This exercise significantly increased the effect of drug premedication.

Keywords

Adis International Limited Salbutamol Force Vital Capacity Salmeterol Beclomethasone 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Adis International Limited 1999

Authors and Affiliations

  • M. Verini
    • 1
  • A. Verrotti
    • 1
  • R. Greco
    • 1
  • F. Chiarelli
    • 1
  1. 1.Department of Medicine, Section of PediatricsUniversity of ChietiItaly

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