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Clinical Drug Investigation

, Volume 17, Issue 2, pp 127–136 | Cite as

Pharmacokinetics of Troglitazone in Patients with Renal Insufficiency

  • Philip W. Knowlton
  • Cho-Ming Loi
  • Artemios B. Vassos
  • Robert A. Blum
  • Joanne I. Brodfuehrer
  • Edward J. Randinitis
  • Allen J. Sedman
  • Jeffrey R. Koup
Clinical Pharmacokinetics
  • 10 Downloads

Abstract

Objective: The pharmacokinetic profiles of troglitazone and two metabolites were evaluated following a single 400mg oral dose of troglitazone in 20 patients with various degrees of renal function.

Methods: Plasma troglitazone and metabolite concentrations were determined by high performance liquid chromatography, and troglitazone free fraction was determined by ultracentrifugation.

Results: Mean maximum plasma concentration and area under the curve for total troglitazone appeared lower in patients with severe renal impairment (SRI) compared with those with normal renal function (NRF). Troglitazone free fraction was higher in patients with SRI (4.85%) than in subjects with NRF (1.66%), producing similar exposure values for unbound troglitazone, the moiety presumed to exert the pharmacological effect. Regression analysis revealed poor correlations of creatinine clearance value with total troglitazone, unbound troglitazone, and metabolite pharmacokinetic parameter values.

Conclusion: These data indicated that renal function does not predict troglitazone pharmacokinetics and systemic exposure to unbound troglitazone is unaltered with renal impairment. Thus, troglitazone dose adjustment based on pharmacokinetics is not required in patients with renal insufficiency.

Keywords

Adis International Limited Normal Renal Function Troglitazone Severe Renal Impairment Clin Drug Invest 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Adis International Limited 1999

Authors and Affiliations

  • Philip W. Knowlton
    • 1
  • Cho-Ming Loi
    • 1
  • Artemios B. Vassos
    • 2
  • Robert A. Blum
    • 3
  • Joanne I. Brodfuehrer
    • 1
  • Edward J. Randinitis
    • 1
  • Allen J. Sedman
    • 2
  • Jeffrey R. Koup
    • 1
  1. 1.Department of Pharmacokinetics and Drug MetabolismParke-Davis Pharmaceutical Research DivisionAnn ArborUSA
  2. 2.Department of Clinical PharmacologyParke-Davis Pharmaceutical Research DivisionAnn ArborUSA
  3. 3.Clinical Pharmacokinetics LaboratoryMillard Fillmore HospitalBuffaloUSA

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