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Clinical Drug Investigation

, Volume 14, Issue 4, pp 294–300 | Cite as

Sustained-Release Isosorbide-5-Mononitrate Supports Captopril Treatment of Heart Failure Due to Coronary Artery Disease

A Pilot Study
Clinical Use

Summary

A pilot placebo-controlled, double-blind, randomised trial was carried out to ascertain whether patients with cardiac failure due to coronary artery disease would benefit further from an additional application of isosorbide-5-mononitrate (IS-5-MN) along with basic Captopril treatment. 21 patients were randomised in this study. Complete haemodynamic data sets of 11 patients in the placebo group and 7 patients in the IS-5-MN group were available for efficacy evaluation. The main target parameter was the mean pulmonary artery pressure (MPAP) during ergometric exercise. After 28 days of treatment with either IS-5-MN or placebo, patients’ MPAP decreased from 43.3 to 35.6mm Hg with IS-5-MN and from 44.2 to 43.8mm Hg in the placebo group under comparable load. Under resting conditions, there was a similar decrease from 27.4 to 22.4mm Hg in the IS-5-MN group and from 26.4 to 25.3mm Hg in the placebo group. The global evaluation of efficacy was judged by the physician as being good in 7 cases in the IS-5-MN group compared with only 1 patient in the placebo group. Two patients in the IS-5-MN group dropped out because of continuous, nonsevere headaches, which were attributed to the use of the test drug.

Keywords

Adis International Limited Captopril Pulmonary Artery Pressure Drug Invest Wall Tension 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Adis International Limited 1997

Authors and Affiliations

  • M. Keck
    • 1
  1. 1.Kurklinik der LVABad Münster am SteinGermany

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