Lack of Interaction Between Pizotifen and the Novel Antimigraine Compound Zolmitriptan in Healthy Volunteers
- 7 Downloads
This double-blind, randomised, two-period crossover study investigated the effect of pizotifen on the pharmacokinetics and tolerability profile of zolmitriptan (formerly 311C90), a novel selective 5-HT1D receptor agonist for acute migraine therapy. 13 healthy volunteers (mean age 31 years, range 19 to 41 years; mean weight 75kg, range 62 to 89kg) received oral pizotifen 1.5mg or placebo once daily for 8 days with a washout period of at least 2 weeks between study periods. Oral zolmitriptan 10mg was administered with the final dose of pizotifen or placebo. Pizotifen did not significantly affect the pharmacokinetic parameters of zolmitriptan, although in 4 subjects the time to peak plasma zolmitriptan concentration (tmax) was increased in the presence of pizotifen (median increase 1.4 hours). Zolmitriptan caused a small, transient, clinically insignificant increase in blood pressure, which was not affected by pizotifen. No clinically relevant changes in heart rate or 12-lead ECGs were observed. One volunteer was withdrawn because of a brief, 5-beat run, asymptomatic episode of ventricular tachycardia 170 minutes after administration with zolmitriptan plus placebo; this was not considered related to the treatment. Zolmitriptan was well tolerated both alone and in combination with pizotifen. Thus, there is no contraindication to the use of zolmitriptan nor a need for dosage modification in patients concomitantly receiving pizotifen.
KeywordsMigraine Sumatriptan Drug Invest Zolmitriptan Pizotifen
Unable to display preview. Download preview PDF.
- 2.Dahlöf C, Diener HC, Goadsby PJ, et al. A multicentre double-blind, placebo-controlled, dose range finding study to investigate the efficacy and safety of oral doses of 311C90 in the acute treatment of migraine. Headache 1995; 35: 292Google Scholar
- 10.Seaber E, On N, Dixon R, et al. The absolute bioavailability and metabolic disposition of the novel anti-migraine compound zolmitriptan. Br J Clin Pharmacol 1997. In pressGoogle Scholar
- 11.Giorgi L, Dixon R, Touw K. Cardiovascular safety of the novel antimigraine compound 311C90 [abstract P18]. Cephalalgia 1995; 15 Suppl. 14: 220Google Scholar