Clinical Drug Investigation

, Volume 12, Issue 1, pp 1–7 | Cite as

NeuRecover-SA™ in the Treatment of Cocaine Withdrawal and Craving

A Pilot Study
  • Julie A. Cold
Clinical Use


The efficacy of NeuRecover-SA™ (formerly called Tropamine+™, and TropaGen™) in the treatment of cocaine withdrawal and craving was evaluated at a state psychiatric hospital. This double-blind, placebo-controlled study was conducted in hospitalised patients with a DSM-III-R diagnosis of cocaine dependence. Eight patients received NeuRecover-SA™ and 4 patients received placebo. No significant difference in patient demographics was found. The mean number of abstinent symptoms (± SEM) declined over the first 4 days of treatment, 10.63 ± 1.32 on day 1 vs 4 ± 1.65 on day 4 in the NeuRecover-SA™ group compared with 7.25 ± 2.93 on day 1 vs 4.25 ± 3.61 on day 4 in the placebo group. Cocaine craving in the NeuRecover-SA™ group on day 1 was 7.88 ± 1.22 vs 2.71 ± 1.22 on day 4 and 5 ± 2.89 on day 1 vs 2 ± 1.68 on day 4 in the placebo group. A Mann-Whitney U test showed no statistically significant differences in abstinent symptomatology between or within treatment groups, or treatment effect in the placebo group. However, a significant decrease (p < 0.05) in cocaine craving occurred in the NeuRecover-SA™ group.

In conclusion, these preliminary results suggest that NeuRecover-SA™ reduces cocaine craving, and larger, longer term studies are warranted.


Cocaine Adis International Limited Drug Invest Trazodone Cocaine Dependence 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Adis International Limited 1996

Authors and Affiliations

  • Julie A. Cold
    • 1
    • 2
  1. 1.Mercer University Southern School of PharmacyAtlantaUSA
  2. 2.Georgia Regional Hospital at AtlantaDecaturUSA

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