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48-Hour Continuous Intragastric pH Fluctuation During Lansoprazole Administration Every Other Day

  • Clinical Pharmacodynamics
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Summary

The inhibitory effect on acid secretion of lansoprazole administered every other day in comparison with cimetidine was investigated in this study. Drugs and dosages were assigned to patients with peptic ulcer as follows: cimetidine 800 and 400mg daily; lansoprazole 30mg every other day. The patients’ intragastric pH was continuously measured, and the time at or above pH 4 (pH 4 holding time) was assessed. Total measurement time and night-time pH 4 holding times were 48.4 ± 3.7% and 56.1 ± 5.7%, respectively, with cimetidine 800mg; 33.7 ± 4.9% and 51.1 ± 7.3%, respectively, with cimetidine 400mg; and 66.1 ±6.1 % and 67.9 ± 5.6%, respectively, with lansoprazole every other day, revealing a significantly more powerful acid suppression in the lansoprazole than in the cimetidine groups. In addition, according to continuous 48-hour intragastric pH measurements, the pH 4 holding time during lansoprazole treatment days was significantly longer than on nontreatment days. Changes in patients’ blood gastrin levels over 48 hours while taking lansoprazole every other day revealed slightly higher values, depending on the time period, but 86% of the patients had fasting gastrin levels of 160 ng/L or less. When lansoprazole was administered every other day, the pH 4 holding time differed between the two days, and gastrin elevation was smaller. We suggest that lansoprazole every other day seems to be pharmacologically capable of being used just for peptic ulcer maintenance therapy.

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References

  1. Jones DB, Howden CW, Burget DW, et al. Acid suppression in duodenal ulcer; a meta-analysis to define optimal dosing with antisecretory drugs. Gut 1987; 28: 1120–7

    Article  PubMed  CAS  Google Scholar 

  2. Burget WD, Chiverton SG, Hunt RH. Is there an optimal degree of acid suppression for healing of duodenal ulcer? Gastroenterology 1990; 99: 345–51

    PubMed  CAS  Google Scholar 

  3. Yamamoto Y, Sakurabayashi S, Sezai S, et al. Evaluation of therapeutic efficiency in gastric ulcer — the effect of acid secretory inhibition and gastric emptying time. Ther Res 1993; 14: 1403–8

    Google Scholar 

  4. Chiverton SG, Hunt RH. Relationship between inhibition of acid secretion and healing of peptic ulcers. Scand J Gastroenterol 1989; 24 Suppl. 166: 43–7

    Article  Google Scholar 

  5. McCullough AJ, Graham DY, Knuff TE, et al. Suppression of nocturnal acid secretion with famotidine accelerates gastric ulcer healing. Gastroenterology 1989; 97: 860–6

    PubMed  CAS  Google Scholar 

  6. Cooperative study group. Double blind comparative study of omeprazole and ranitidine in patients with duodenal or gastric ulcer: a multicentre trial. Gut 1990; 31: 653–6

    Article  Google Scholar 

  7. McFarland RJ, Bateson MC, Green RB, et al. Omeprazole provides quicker symptom relief and duodenal ulcer healing than ranitidine. Gastroenterology 1990; 98: 278–83

    PubMed  CAS  Google Scholar 

  8. Yamamoto Y, Hirano M. The role of acid suppression in treating peptic ulcer. Proc Jap Soc Gast Sec Res 1994; 26: 77–80

    Google Scholar 

  9. Lind T, Cederberg C, Forssell H, et al. Relationship between reduction of gastric acid secretion and plasma gastrin concentration during omeprazole treatment. Scand J Gastroenterol 1988; 23: 1259–66

    Article  PubMed  CAS  Google Scholar 

  10. Havu N. Enterochromaffin-like cell carcinoids of gastric mucosa in rats after life-long inhibition of gastric acid secretion. Digestion 1986; 35: 42–55

    Article  PubMed  Google Scholar 

  11. Ekman L, Hansson E, Havu N, et al. Toxicological studies on omeprazole. Scand J Gastroenterol 1985; 20 Suppl. 108: 53–70

    Google Scholar 

  12. Baak LC, Jansen MJ, Biemond I, et al. Weekend treatment with 20 and 40mg omeprazole: effect on intragastric pH, fasting and postprandial serum gastrin, and serum pepsinogens. Gut 1991; 32: 977–82

    Article  PubMed  CAS  Google Scholar 

  13. Lauritsen K, Andersen BN, Laursen LS, et al. Omeprazole 20mg three days a week and 10mg daily in prevention of duodenal ulcer relapse. Gastroenterology 1991; 100: 663–9

    PubMed  CAS  Google Scholar 

  14. Satoh H, Inatomi N, Nagaya H, et al. Antisecretory and antiulcer activities of a novel proton pump inhibitor AG-1749 in dogs and rats. J Pharmacol Exp Ther 1989; 248: 806–15

    PubMed  CAS  Google Scholar 

  15. Nagaya H, Satoh H, Maki Y. Possible mechanism for the inhibitor AG-1749 in isolated canine parietal cells. J Pharmacol Exp Ther 1990; 252: 1289–95

    PubMed  CAS  Google Scholar 

  16. Yamamoto Y, Sakurabayashi S, Sezai S, et al. Problem and significance of 24-hr continuous measurement of intragastric pH. Gastroenterol Endosc 1993; 35: 2432–7

    Google Scholar 

  17. Delchier JC, Roudot-Thoraval F, Stanescu L, et al. Maintenance of intragastric pH>4 with famotidine in duodenal ulcer patients: factors influencing drug requirements. Gut 1994; 35: 750–4

    Article  PubMed  CAS  Google Scholar 

  18. Takeda M, Iwakin C, Demura H, et al. Fundamental and clinical investigation of gastrin RIA kit II. Clin Endocrinol 1993; 31: 1123–8

    Google Scholar 

  19. Walan A, Bader JP, Classen M, et al. Effect of omeprazole and ranitidine on ulcer healing and relapse rates in patients with benign gastric ulcer. N Engl J Med 1989; 320: 69–75

    Article  PubMed  CAS  Google Scholar 

  20. Hallerback B, Unge P, Carling L, et al. Omeprazole or ranitidine in long-term treatment of reflux esophagitis. Gastroenterology 1994; 107: 1305–11

    PubMed  CAS  Google Scholar 

  21. Biemond I, Klinkenberg-Knol EC, Lamers CBHW, et al. Serum pepsinogens after interruption of long-term maintenance therapy with omeprazole in patients with reflux esophagitis. Dig Dis Sci 1993; 38: 932–6

    Article  PubMed  CAS  Google Scholar 

  22. Yamamoto Y, Sezai S, Sakurabayashi S, et al. Omeprazole versus cimetidine in the treatment of gastric ulcers. Optimal duration of acid suppression. Drug Invest 1994; 8: 377–82

    Google Scholar 

  23. Hewson EG, Yeomans ND, Angus PW, et al. Effect of ‘weekend therapy’ with omeprazole on basal and stimulated acid secretion and fasting plasma gastrin in duodenal ulcer patients. Gut 1988; 29: 1715–20

    Article  PubMed  CAS  Google Scholar 

  24. Lamberts R, Creutzfeldt W, Stuber HG, et al. Long-term omeprazole therapy in peptic ulcer disease: gastrin, endocrine cell growth, and gastritis. Gastroenterology 1993; 104: 1356–70

    PubMed  CAS  Google Scholar 

  25. Brunner G, Arnold R, Henning U, et al. An open trial of long-term therapy with lansoprazole in patients with peptic ulceration resistant to extended high-dose ranitidine treatment. Aliment Pharmacol Ther 1993; 7 Suppl. 1: 51–5

    PubMed  Google Scholar 

  26. Lind T, Cederberg C, Olausson M, et al. 24-Hour intragastric acidity and plasma gastrin after omeprazole treatment and after proximal gastric vagotomy in duodenal ulcer patients. Gastroenterology 1990; 99: 1593–8

    PubMed  CAS  Google Scholar 

  27. Levant JA, Walsh JH, Isenberg JI. Stimulation of gastric secretion and gastrin release by single oral doses of calcium carbonate in man. N Engl J Med 1973; 289: 555–8

    Article  PubMed  CAS  Google Scholar 

  28. Higgs RH, Smyth RD, Castell DO. Gastric alkalinization: effect on lower-esophageal spincter pressure and serum gastrin. N Engl J Med 1974; 291: 486–90

    Article  PubMed  CAS  Google Scholar 

  29. Peters MN, Feldman M, Walsh JH, et al. Effect of gastric alkalinization on serum gastrin concentrations in humans. Gastroenterology 1983; 85: 35–9

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Division of Gastroenterology, Tokyo Metropolitan Police Hospital, 2-10-41, Fujimi, Chiyoda-ku 102, Tokyo, Japan

    Yoshihiro Yamamoto, Shuichi Sezai, Shin Sakumbayashi, Masanori Hirano & Hiroshi Oka

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  1. Yoshihiro Yamamoto
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  2. Shuichi Sezai
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  3. Shin Sakumbayashi
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  4. Masanori Hirano
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  5. Hiroshi Oka
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Yamamoto, Y., Sezai, S., Sakumbayashi, S. et al. 48-Hour Continuous Intragastric pH Fluctuation During Lansoprazole Administration Every Other Day. Clin. Drug Invest. 10, 228–234 (1995). https://doi.org/10.2165/00044011-199510040-00006

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  • DOI: https://doi.org/10.2165/00044011-199510040-00006

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