Clinical Drug Investigation

, Volume 10, Issue 4, pp 228–234 | Cite as

48-Hour Continuous Intragastric pH Fluctuation During Lansoprazole Administration Every Other Day

  • Yoshihiro Yamamoto
  • Shuichi Sezai
  • Shin Sakumbayashi
  • Masanori Hirano
  • Hiroshi Oka
Clinical Pharmacodynamics
  • 5 Downloads

Summary

The inhibitory effect on acid secretion of lansoprazole administered every other day in comparison with cimetidine was investigated in this study. Drugs and dosages were assigned to patients with peptic ulcer as follows: cimetidine 800 and 400mg daily; lansoprazole 30mg every other day. The patients’ intragastric pH was continuously measured, and the time at or above pH 4 (pH 4 holding time) was assessed. Total measurement time and night-time pH 4 holding times were 48.4 ± 3.7% and 56.1 ± 5.7%, respectively, with cimetidine 800mg; 33.7 ± 4.9% and 51.1 ± 7.3%, respectively, with cimetidine 400mg; and 66.1 ±6.1 % and 67.9 ± 5.6%, respectively, with lansoprazole every other day, revealing a significantly more powerful acid suppression in the lansoprazole than in the cimetidine groups. In addition, according to continuous 48-hour intragastric pH measurements, the pH 4 holding time during lansoprazole treatment days was significantly longer than on nontreatment days. Changes in patients’ blood gastrin levels over 48 hours while taking lansoprazole every other day revealed slightly higher values, depending on the time period, but 86% of the patients had fasting gastrin levels of 160 ng/L or less. When lansoprazole was administered every other day, the pH 4 holding time differed between the two days, and gastrin elevation was smaller. We suggest that lansoprazole every other day seems to be pharmacologically capable of being used just for peptic ulcer maintenance therapy.

Keywords

Cimetidine Omeprazole Lansoprazole Drug Invest Gastrin Level 

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Copyright information

© Adis International Limited 1995

Authors and Affiliations

  • Yoshihiro Yamamoto
    • 1
  • Shuichi Sezai
    • 1
  • Shin Sakumbayashi
    • 1
  • Masanori Hirano
    • 1
  • Hiroshi Oka
    • 1
  1. 1.Division of GastroenterologyTokyo Metropolitan Police HospitalTokyoJapan

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