Clinical Drug Investigation

, Volume 9, Issue 3, pp 166–170 | Cite as

Comparative Efficacy of Pefloxacin and Cefalothin/Cefalexin with or without Gentamicin in the Treatment of Post-Traumatic or Postsurgical Osteomyelitis

  • H. L. A. Defino
  • J. E. Moretti
  • A. E. R. Fuentes
Original Research Clinical Use


A nonblind, randomised clinical trial was conducted to assess the efficacy of pefloxacin versus cefalothin/cefalexin with or without gentamicin in conjunction with surgery in 60 patients with post-traumatic or postsurgical osteomyelitis. After surgical intervention and 4 weeks of treatment, signs of osteomyelitis were absent from 92.5% of patients treated with pefloxacin and 90.9% of those treated with cephalosporins with or without gentamicin. At the end of a further 12-month follow-up period, a small proportion of patients experienced relapse in each group, but osteomyelitis remained undetectable in a similar proportion of patients (approximately 85% in each cohort). These results suggest that pefloxacin is of equivalent efficacy to cefalothin/cefalexin ± gentamicin as adjunct therapy to surgery in patients with postsurgical or post-traumatic osteomyelitis.


Adis International Limited Gentamicin Cephalosporin Osteomyelitis Drug Invest 


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Copyright information

© Adis International Limited 1995

Authors and Affiliations

  • H. L. A. Defino
    • 1
  • J. E. Moretti
    • 1
  • A. E. R. Fuentes
    • 1
  1. 1.Department of Surgery, Orthopaedics and Traumatology, Faculty of Medicine of Ribeirão PretoUniversity of São PauloRibeirão PretoBrazil

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