Clinical Drug Investigation

, Volume 9, Issue 3, pp 166–170 | Cite as

Comparative Efficacy of Pefloxacin and Cefalothin/Cefalexin with or without Gentamicin in the Treatment of Post-Traumatic or Postsurgical Osteomyelitis

  • H. L. A. Defino
  • J. E. Moretti
  • A. E. R. Fuentes
Original Research Clinical Use


A nonblind, randomised clinical trial was conducted to assess the efficacy of pefloxacin versus cefalothin/cefalexin with or without gentamicin in conjunction with surgery in 60 patients with post-traumatic or postsurgical osteomyelitis. After surgical intervention and 4 weeks of treatment, signs of osteomyelitis were absent from 92.5% of patients treated with pefloxacin and 90.9% of those treated with cephalosporins with or without gentamicin. At the end of a further 12-month follow-up period, a small proportion of patients experienced relapse in each group, but osteomyelitis remained undetectable in a similar proportion of patients (approximately 85% in each cohort). These results suggest that pefloxacin is of equivalent efficacy to cefalothin/cefalexin ± gentamicin as adjunct therapy to surgery in patients with postsurgical or post-traumatic osteomyelitis.


Adis International Limited Gentamicin Cephalosporin Osteomyelitis Drug Invest 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Adis International Limited 1995

Authors and Affiliations

  • H. L. A. Defino
    • 1
  • J. E. Moretti
    • 1
  • A. E. R. Fuentes
    • 1
  1. 1.Department of Surgery, Orthopaedics and Traumatology, Faculty of Medicine of Ribeirão PretoUniversity of São PauloRibeirão PretoBrazil

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