Comparative Efficacy of Pefloxacin and Cefalothin/Cefalexin with or without Gentamicin in the Treatment of Post-Traumatic or Postsurgical Osteomyelitis
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A nonblind, randomised clinical trial was conducted to assess the efficacy of pefloxacin versus cefalothin/cefalexin with or without gentamicin in conjunction with surgery in 60 patients with post-traumatic or postsurgical osteomyelitis. After surgical intervention and 4 weeks of treatment, signs of osteomyelitis were absent from 92.5% of patients treated with pefloxacin and 90.9% of those treated with cephalosporins with or without gentamicin. At the end of a further 12-month follow-up period, a small proportion of patients experienced relapse in each group, but osteomyelitis remained undetectable in a similar proportion of patients (approximately 85% in each cohort). These results suggest that pefloxacin is of equivalent efficacy to cefalothin/cefalexin ± gentamicin as adjunct therapy to surgery in patients with postsurgical or post-traumatic osteomyelitis.
KeywordsAdis International Limited Gentamicin Cephalosporin Osteomyelitis Drug Invest
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