Clinical Drug Investigation

, Volume 9, Issue 2, pp 79–87 | Cite as

Thymostimulin in Association with Chemotherapy in Breast Cancer Patients with Bone Metastases

  • S. Gonnelli
  • R. Petrioli
  • C. Cepollaro
  • R. Palmieri
  • A. Aquino
  • C. Gennari
Original Research Clinical Use


40 patients with predominantly osteolytic bone metastases from breast cancer, in whom first-line chemotherapy had failed, were randomly allocated to 2 groups: 20 patients received chemotherapy plus thymostimulin (CHT + Th), and 20 patients received chemotherapy alone (CHT). The occurrence of infections, response rate, bone markers and bone pain were evaluated after 3 and 6 months of treatment. The infection rate was lower in the CHT + Th group than in the CHT group (p<0.05). At the 6th month the average administered dose intensity was significantly higher in the CHT + Th group (p<0.05). Pain, as assessed by a visual analogue scale, showed a significant reduction in both groups. The hydroxyproline/creatinine ratio showed a significant reduction (p<0.05) only in CHT + Th treated patients. After 6 months of treatment, a partial response was observed in 6 of 19 evaluable patients in the CHT + Th group and in 4 of 17 evaluable patients in the CHT group. Our findings suggest that the addition of thymostimulin to chemotherapy in breast cancer patients with bone metastases reduces the infection rate and allows for the administration of the planned dose intensity.


Breast Cancer Adis International Limited Bone Metastasis Eastern Cooperative Oncology Group Drug Invest 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Adis International Limited 1995

Authors and Affiliations

  • S. Gonnelli
    • 1
  • R. Petrioli
    • 2
  • C. Cepollaro
    • 1
  • R. Palmieri
    • 1
  • A. Aquino
    • 2
  • C. Gennari
    • 1
  1. 1.Institute of Internal MedicineUniversity of SienaSienaItaly
  2. 2.Division of Medical OncologyUniversity of SienaSienaItaly

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