Drugs & Therapy Perspectives

, Volume 24, Issue 4, pp 17–20 | Cite as

Efficacy of antiepileptic drugs (AEDs) in the treatment of neuropathic pain varies according to the type of pain

Disease Management


Carbamazepine Neuropathic Pain Gabapentin Lamotrigine Topiramate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Eisenberg E, River Y, Shifrin A, et al. Antiepileptic drugs in the treatment of neuropathic pain. Drugs 2007; 67(9): 1265–89PubMedCrossRefGoogle Scholar
  2. 2.
    Johannessen Landmark C. Antiepileptic drugs in non-epilepsy disorders: relations between mechanisms of action and clinical efficacy. CNS Drugs 2008; 22(1): 27–47PubMedCrossRefGoogle Scholar
  3. 3.
    Campbell FG, Graham JG, Zilkha KJ. Clinical trial of carbamazepine (Tegretol) in trigeminal neuralgia. J Neurosurg Neurol Psychiatry 1966; 29: 265–7CrossRefGoogle Scholar
  4. 4.
    Gomez-Perez FJ, Choza R, Rios JM, et al. Nortriptyline-fluphenazine vs. carbamazepine in the symptomatic treatment of diabetic neuropathy. Arch Med Res 1996; 27(4): 525–9PubMedGoogle Scholar
  5. 5.
    Harke H, Gretenkort P, Ladleif HU, et al. The response of neuropathic pain and pain in complex regional pain syndrome I to carbamazepine and sustained-release morphine in patients pretreated with spinal cord stimulation: a double-blinded randomized study. Anesth Analg 2001; 92(2): 488–95PubMedCrossRefGoogle Scholar
  6. 6.
    Lindström P. The analgesic effect of carbamazepine in trigeminal neuralgia. Pain 1987; 4: S85CrossRefGoogle Scholar
  7. 7.
    Dogra S, Beydoun S, Mazzola J, et al. Oxcarbazepine in painful diabetic neuropathy: a randomized placebo-controlled study. Eur J Pain 2005; 9(5): 543–54PubMedCrossRefGoogle Scholar
  8. 8.
    Grosskopf J, Mazzola J, Wan Y. A randomized, placebo-controlled study of oxcarbazepine in painful diabetic neuropathy. Acta Neurol Scand 2006; 114(3): 177–80PubMedCrossRefGoogle Scholar
  9. 9.
    Gilron I, Booher SL, Rowan JS, et al. Topiramate in trigeminal neuralgia: a randomized, placebo-controlled multiple crossover pilot study. Clin Neuropharmacol 2001; 24(2): 109–12PubMedCrossRefGoogle Scholar
  10. 10.
    Khoromi S, Patsalides A, Parada S, et al. Topiramate in chronic lumbar radicular pain. J Pain 2005; 6(12): 829–36PubMedCrossRefGoogle Scholar
  11. 11.
    Gilron I, Bailey JM, Tu D, et al. Morphine, gabapentin, or their combination for neuropathic pain. N Engl J Med 2005; 352(13): 1324–34PubMedCrossRefGoogle Scholar
  12. 12.
    Vinik AI, Tuchman M, Safirstein B, et al. Lamotrigine for treatment of pain associated with diabetic neuropathy: results of two randomized, double-blind, placebo-controlled studies. Pain 2007; 128(1–2): 169–79PubMedCrossRefGoogle Scholar
  13. 13.
    Zakrzewska JM, Chaudhry Z, Nurmikko TJ, et al. Lamotrigine (lamictal) in refractory trigeminal neuralgia: results from a double-blind placebo controlled crossover trial. Pain 1997; 73(2): 223–30PubMedCrossRefGoogle Scholar
  14. 14.
    Vestergaard K, Andersen G, Gottrup H, et al. Lamotrigine for central poststroke pain: a randomized controlled trial. Neurology 2001; 56(2): 184–90PubMedCrossRefGoogle Scholar
  15. 15.
    Finnerup NB, Sindrup SH, Bach FW, et al. Lamotrigine in spinal cord injury pain: a randomized controlled trial. Pain 2002; 96(3): 375–83PubMedCrossRefGoogle Scholar
  16. 16.
    Simpson DM, Olney R, McArthur JC, et al. A placebo-controlled trial of lamotrigine for HIV-associated neuropathy. Neurology 2000; 54(11): 2115–9PubMedCrossRefGoogle Scholar
  17. 17.
    Simpson DM, McArthur JC, Olney R, et al. Lamotrigine for HIV-associated painful sensory neuropathies: a placebo-controlled trial. Neurology 2003; 60(9): 1508–14PubMedCrossRefGoogle Scholar
  18. 18.
    Freynhagen R, Strojek K, Griesing T, et al. Efficacy of pregabalin in neuropathic pain evaluated in a 12-week, randomised, double-blind, multicentre, placebo-controlled trial of flexible and fixed-dose regimens. Pain 2005; 115(3): 254–63PubMedCrossRefGoogle Scholar
  19. 19.
    Richter RW, Portenoy R, Sharma U, et al. Relief of painful diabetic peripheral neuropathy with pregabalin: a randomized, placebo-controlled trial. J Pain 2005; 6(4): 253–60PubMedCrossRefGoogle Scholar
  20. 20.
    Lesser H, Sharma U, LaMoreaux L, et al. Pregabalin relieves symptoms of painful diabetic neuropathy: a randomized controlled trial. Neurology 2004; 63(11): 2104–10PubMedCrossRefGoogle Scholar
  21. 21.
    Rosenstock J, Tuchman M, LaMoreaux L, et al. Pregabalin for the treatment of painful diabetic peripheral neuropathy: a double-blind, placebo-controlled trial. Pain 2004; 110(3): 628–38PubMedCrossRefGoogle Scholar
  22. 22.
    Sabatowski R, Gálvez R, Cherry DA, et al. Pregabalin reduces pain and improves sleep and mood disturbances in patients with post-herpetic neuralgia: results of a randomized, placebo-controlled clinical trial. Pain 2004; 109(1–2): 26–35PubMedCrossRefGoogle Scholar
  23. 23.
    Dworkin RH, Corbin AE, Young JP Jr, et al. Pregabalin for the treatment of postherpetic neuralgia: a randomized, placebo controlled trial. Neurology 2003; 60(8): 1274–83PubMedCrossRefGoogle Scholar
  24. 24.
    vanSeventer R, Feister HA, Young JP, et al. Efficacy and tolerability of twice-daily pregabalin for treating pain and related sleep interference in postherpetic neuralgia: a 13-week, randomized trial. Curr Med Res Opin 2006; 22(2): 375–84PubMedCrossRefGoogle Scholar
  25. 25.
    Rowbotham MC, Manville NS, Ren J. Pilot tolerability and effectiveness study of levetiracetam for postherpetic neuralgia. Neurology 2003; 61(6): 866–7PubMedCrossRefGoogle Scholar
  26. 26.
    Todorov AA, Kolchev CB, Todorov AB. Taigabine and gabapentin for the management of chronic pain. Clin J Pain 2005; 21(4): 358–61PubMedCrossRefGoogle Scholar
  27. 27.
    Otto M, Bach FW, Jensen TS, et al. Valproic acid has no effect on pain in polyneuropathy: a randomized, controlled trial. Neurology 2004; 62(2): 285–8PubMedCrossRefGoogle Scholar
  28. 28.
    Kochar DK, Garg P, Bumb RA, et al. Divalproex sodium in the management of post-herpetic neuralgia: a randomized double-blind placebo-controlled study. Q J Med 2005; 98(1): 29–34CrossRefGoogle Scholar
  29. 29.
    McCleane GJ. Intravenous infusion of phenytoin relieves neuropathic pain: a randomized, double-blind, placebo-controlled, crossover study. Anesth Analg 1999; 89(4): 985–8PubMedGoogle Scholar

Copyright information

© Adis Data Information BV 2008

Personalised recommendations