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Drugs & Therapy Perspectives

, Volume 21, Issue 1, pp 1–4 | Cite as

Letrozole is an effective option in the treatment of early-stage or advanced breast cancer in postmenopausal women

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Letrozole, a highly specific, nonsteroidal third-generation aromatase inhibitor, is a potent inhibitor of estrogen synthesis that is of benefit to postmenopausal breast cancer patients. Extended adjuvant therapy with letrozole 2.5 mg/day improves disease-free survival in early breast cancer previously treated with tamoxifen; as neoadjuvant therapy, it is superior to tamoxifen. In advanced breast cancer, letrozole 2.5 mg/day is superior to tamoxifen 20 mg/day as first-line therapy, and as effective as anastrozole 1 mg/day and at least as effective as megestrol acetate 160 mg/day as second-line therapy. Letrozole is tolerated at least as well as tamoxifen, anastrozole or megestrol acetate.

Postmenopausal breast cancer common

In the western world, breast cancer is the most common cancer affecting women.[1] Approximately 80% of breast cancers occur in postmenopausal women, and they are the second leading cause of death in this group of women in the US.[2]

Endocrine therapy a mainstay

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© Adis Data Information BV 2005

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