Drugs & Therapy Perspectives

, Volume 19, Issue 8, pp 5–6 | Cite as

Clozapine in prevention of suicide in patients with schizophrenia: profile report

  • Michael Sernyak
Drugs and Profile Reports


Schizophrenia Clozapine Olanzapine Suicide Attempt Antipsychotic Medication 


  1. 1.
    Wagstaff AJ, Perry CM. Clozapine: in prevention of suicide in patients with schizophrenia or schizoaffective disorder. CNS Drugs 2003; 17(4): 273–80PubMedCrossRefGoogle Scholar
  2. 2.
    Sernyak M. Clozapine and prevention of suicide in schizophrenia: a viewpoint. CNS Drugs 2003; 17(4): 281–2CrossRefGoogle Scholar
  3. 3.
    Wagstaff AJ, Bryson HM. Clozapine: a review of its pharmacological properties and therapeutic use in patients with schizophrenia who are unresponsive to or intolerant of classical antipsychotic agents. CNS Drugs 1995; 4(5): 370–400CrossRefGoogle Scholar
  4. 4.
    Masellis M, Basile VS, Özdemir V, et al. Pharmacogenetics of antipsychotic treatment: lessons learned from clozapine. Biol Psychiatry 2000 Feb 1; 47(3): 252–66PubMedCrossRefGoogle Scholar
  5. 5.
    Edge SC, Markowitz JS, Devane CL. Clozapine drug-drug interactions: a review of the literature. Hum Psychopharmacol 1997 Jan; 12: 5–20CrossRefGoogle Scholar
  6. 6.
    Meltzer HY, Alphs L, Green AI, et al. Clozapine treatment for suicidality in schizophrenia: international suicide prevention trial (InterSePT). Arch Gen Psychiatry 2003; 60: 82–91PubMedCrossRefGoogle Scholar
  7. 7.
    Spivak B, Roitman S, Vered Y, et al. Diminished suicidal and aggressive behavior, high plasma norepinephrine levels, and serum triglyceride levels in chronic neuroleptic-resistant schizophrenic patients maintained on clozapine. Clin Neuropharmacol 1998 Jul; 21(4): 245–50PubMedGoogle Scholar
  8. 8.
    Ciapparelli A, Dell’Osso L, Pini S, et al. Clozapine for treatment-refractory schizophrenia, schizoaffective disorder, and psychotic bipolar disorder: a 24-month naturalistic study. J Clin Psychiatry 2000 May; 61(5): 329–34PubMedCrossRefGoogle Scholar
  9. 9.
    Meltzer HY, Okayli G. Reduction of suicidality during clozapine treatment of neuroleptic-resistant schizophrenia: impact on risk-benefit assessment. Am J Psychiatry 1995 Feb; 152(2): 183–90PubMedGoogle Scholar
  10. 10.
    Modai I, Hirschmann S, Rava A, et al. Sudden death in patients receiving clozapine treatment: a preliminary investigation. J Clin Psychopharmacol 2000 Jun; 20(3): 325–7PubMedCrossRefGoogle Scholar
  11. 11.
    Reid WH, Mason M, Hogan T. Suicide prevention effects associated with clozapine therapy in schizophrenia and schizoaffective disorder. Psychiatr Serv 1998 Aug; 49(8): 1029–33PubMedGoogle Scholar
  12. 12.
    Sernyak MJ, Desai R, Stolar M, et al. Impact of clozapine on completed suicide. Am J Psychiatry 2001 Jun; 158(6): 931–7PubMedCrossRefGoogle Scholar
  13. 13.
    Walker AM, Lanza LL, Arellano F, et al. Mortality in current and former users of clozapine. Epidemiology 1997 Nov; 8(6): 671–7PubMedGoogle Scholar

Copyright information

© Adis Data Information BV 2003

Authors and Affiliations

  • Michael Sernyak
    • 1
  1. 1.Yale School of MedicineWest HavenUSA

Personalised recommendations