Drugs & Therapy Perspectives

, Volume 12, Issue 6, pp 14–16 | Cite as

HRT increases likelihood of venous thromboembolism, but overall risk small

Drug Reactions and Interactions


Adis International Limited Anxiety Disorder Hormone Replacement Therapy Generalize Anxiety Disorder Venous Thromboembolism 
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  1. 1.
    Committee on Safety of Medicines, Medicines Control Agency. Risk of venous thromboembolism with hormone replacement therapy. Curr Probl Pharmacovigilance 1996; 22: 9–10Google Scholar
  2. 2.
    Castellsague J, Pérez Gutthann S, García Rodríguez LA. Recent epidemiological studies of the association between hormone replacement therapy and venous thromboembolism: a review. Drug Saf 1998 Feb; 18(2): 117–23PubMedCrossRefGoogle Scholar
  3. 3.
    A report from the Boston Collaborative Drug Surveillance Program, Boston University Medical Center. Surgically confirmed gallbladder, venous thromboembolism, and breast tumors in relation to postmenopausal estrogen therapy. N Engl J Med 1974; 290: 15–9CrossRefGoogle Scholar
  4. 4.
    Daly E, Vessey MP, Hawkins MM, et al. Case-control study of venous thromboembolism disease and use of hormone replacement therapy. Lancet 1996; 348: 977–80PubMedCrossRefGoogle Scholar
  5. 5.
    Jick H, Derby L. The risk of hospitalization for idiopathic venous thromboembolism among users of postmenopausal estrogens. Lancet 1996; 348: 981–3PubMedCrossRefGoogle Scholar
  6. 6.
    Pérez-Gutthann S, García-Rodríguez LA, Castellsague J, et al. Hormone replacement therapy and risk of venous thromboembolism: population based case-control study. BMJ 1997; 314: 796–800PubMedCrossRefGoogle Scholar
  7. 7.
    Varas C, García-Rodríguez LA, Cattaruzzi C, et al. Hormone replacement therapy and the risk of hospitalization for venous thromboembolism: a population-based study in southern Europe. Am J Epidemiol 1998 Feb 15; 147(4): 387–90CrossRefGoogle Scholar
  8. 8.
    Grodstein F, Stampfer MJ, Goldhaber SZ, et al. Prospective study of exogenous hormones and risk of pulmonary embolism in women. Lancet 1996; 348: 983–7PubMedCrossRefGoogle Scholar
  9. 9.
    Vandenbroucke JP, Koster T, Briet E, et al. Increased risk of venous thrombosis in oral-contraceptive users who are carriers of factor V Leiden mutation. Lancet 1994; 344: 1454–7CrossRefGoogle Scholar

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© Adis International Limited 1998

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