Drugs & Therapy Perspectives

, Volume 11, Issue 4, pp 10–13 | Cite as

Polydipsia-hyponatraemia can be life-threatening if unrecognised

New Drugs and Disease Management


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  1. 1.
    Vieweg WVR, Leadbetter RA. Polydipsia-hyponatraemia syndrome: epidemiology, clinical features and treatment. CNS Drugs 1997 Feb; 7(2): 121–38CrossRefGoogle Scholar
  2. 2.
    Spigset O, Hedenmalm K. Hyponatraemia and the syndrome of inappropriate antidiuretic hormone secretion (SIADH) induced by psychotropic drugs. Drug Saf 1995; 12(3): 209–25PubMedCrossRefGoogle Scholar
  3. 3.
    Culpepper RM, Hebert SC, Andreoli TE. The posterior pituitary and water metabolism. In: Wilson JD, Foster EW, editors. Williams textbook of endocrinology. 7th ed. Philadelphia: WB Saunders, 1985: 614–52Google Scholar
  4. 4.
    Thomas A, Verbalis JG. Hyponatraemia and the syndrome of inappropriate antidiuretic hormone secretion associated with drug therapy in psychiatric patients. CNS Drugs 1995; 4(3): 357–69CrossRefGoogle Scholar
  5. 5.
    Crammer JL. Drinking, thirst, and water intoxication. Br J Psychiatry 1991; 159: 83–9PubMedCrossRefGoogle Scholar
  6. 6.
    Jose CJ, Perez-Cruet J. Incidence and morbidity of self-induced water intoxication in state mental hospital patients. Am J Psychiatry 1979; 136: 221–2PubMedGoogle Scholar
  7. 7.
    Blum A. The possible role of tobacco cigarette smoking in hyponatremia of long-term psychiatric patients. JAMA 1984; 252: 2864–5PubMedCrossRefGoogle Scholar
  8. 8.
    Ohsawa H, Kishimoto T, Hirai M, et al. An epidemiological study on hyponatremia in psychiatric patients in mental hospitals in Nara Prefecture. Jpn J Psychiatry Neurol 1992; 46(4): 883–9PubMedGoogle Scholar
  9. 9.
    Kowacs L, Robertson GL. Syndrome of inappropriate antidiuresis. Endocrinol Metab Clin North Am 1992; 21: 859–75Google Scholar
  10. 10.
    Riggs AT, Dysken MW, Kim SW, et al. A review of disorders of water homeostasis in psychiatric patients. Psychosomatics 1991; 32: 133–48PubMedCrossRefGoogle Scholar
  11. 11.
    Verghese C, de Leon J, Simpson GM. Neuroendocrine factors influencing polydipsia in psychiatric patients: an hypothesis. Neuropsychopharmacology 1993; 9: 157–66PubMedGoogle Scholar
  12. 12.
    Goldman MB. A rational approach to disorders of water balance in psychiatric patients. Hosp Community Psychiatry 1991; 42: 488–94PubMedGoogle Scholar
  13. 13.
    Vieweg WVR, Rowe WT, David JJ, et al. Oral sodium chloride in the management of schizophrenic patients with self-induced water intoxication. J Clin Psychiatry 1985; 46: 16–9PubMedGoogle Scholar

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