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Gastric Toxicity: A Problem with Low-Dose Aspirin

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References

  1. Low-dose aspirin beneficial in myocardial infarction. Drug Ther Perspect 1997; 10 (4): 6–8

    Article  Google Scholar 

  2. Guslandi M. Gastric toxicity of antiplatelet therapy with low-dose aspirin. Drugs 1997 Jan; 53 (1): 1–5

    Article  PubMed  CAS  Google Scholar 

  3. Bochner F, Lloyd JV. Aspirin for myocardial infarction: clinical pharmacokinetic considerations. Clin Pharmacokinet 1995; 28 (6): 433–8

    Article  PubMed  CAS  Google Scholar 

  4. Konturek JW, Dembinski A, Stoll R, et al. Mucosal adaptation to aspirin-induced gastric damage in humans: studies on blood flow, gastric mucosal growth and neutrophil activation. Gut 1994; 35: 1197–204

    Article  PubMed  CAS  Google Scholar 

  5. Savon JJ, Allen ML, DiMarino AJ, et al. Gastrointestinal blood loss with low dose (325mg) plain and enteric-coated aspirin administration. Am J Gastroenterol 1995; 90: 581–5

    PubMed  CAS  Google Scholar 

  6. Slattery J, Warlow CP, Shorrock CJ, et al. Risks of gastrointestinal bleeding during secondary prevention of vascular events with aspirin — analysis of gastrointestinal bleeding during the UK-TIA trial. Gut 1995; 37: 509–11

    Article  PubMed  CAS  Google Scholar 

  7. Weil J, Colin-Jones D, Langman MJS, et al. Prophylactic aspirin and risk of peptic ulcer bleeding. Br Med J 1995; 310: 827–30

    Article  CAS  Google Scholar 

  8. Kaufman DW, Kelly JP, Sheehan JE, et al. Nonsteroidal anti-inflammatory drug use in relation to major upper gastrointestinal bleeding. Clin Pharmacol Ther 1993; 53: 485–94

    Article  PubMed  CAS  Google Scholar 

  9. Lee M, Cruer B, Feldman M. Dose effects of aspirin and gastric prostaglandins and stomach mucosal injury. Ann Intern Med 1994; 120: 184–9

    PubMed  CAS  Google Scholar 

  10. Lanza F, Peace K, Gustitus L, et al. A blinded endoscopic comparative study of misoprostol versus sucralfate and placebo in the prevention of aspirin-induced gastric and duodenal ulceration. Am J Gastroenterol 1988; 83: 143–6

    PubMed  CAS  Google Scholar 

  11. Goddard AF, Donnelly MT, Filipowicz B, et al. Low-dose misoprostol as prophylaxis against low-dose aspirin-induced gastroduodenal mucosal injury [abstract]. Gut 1996; 39 Suppl. 1: A33

    Google Scholar 

  12. British National Formulary No. 33. London: The Pharmaceutical Press, 1997 Mar: 39

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Gastric Toxicity: A Problem with Low-Dose Aspirin. Drugs Ther. Perspect 10, 12–14 (1997). https://doi.org/10.2165/00042310-199710040-00004

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