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American Journal of Cancer

, Volume 2, Issue 1, pp 15–26 | Cite as

Treatment Options for Chemotherapy-Induced Nausea and Vomiting

Current and Future
  • Jens M. Stieler
  • Peter Reichardt
  • Hanno Riess
  • Helmut Oettle
Review Article

Abstract

Nausea and emesis are among the most important adverse effects of cytostatic therapy. They can be distinguished between anticipatory, acute and delayed nausea and vomiting. The different mechanisms of action of the current antiemetic drugs, serotonin (5-HT3) receptor antagonists, dopamine antagonists and corticosteroids are reviewed and their efficacy is discussed. The potential benefits of the new antiemetic neurokinin receptor (NK1) antagonists as well as other possible ways to influence emesis and to combine antiemetic drugs are explained. The best control of anticipatory emesis is achieved by adequate control of acute and delayed emesis and nausea from the very start of chemotherapy. At present, the most effective regimen for control of acute emesis is administration of a 5-HT3 receptor antagonist plus a corticosteroid and an NK1 antagonist on day 1. The control of delayed nausea and emesis consists of good control of acute emesis, application of an NK1 antagonist on day 1, possibly supplemented with metoclopramide combined with a corticosteroid on the subsequent days.

Keywords

Ondansetron Metoclopramide Cisapride Granisetron Tropisetron 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgements

The authors have provided no information on sources of funding or on conflicts of interest directly relevant to the content of this review.

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Copyright information

© Adis International Limited 2003

Authors and Affiliations

  • Jens M. Stieler
    • 1
  • Peter Reichardt
    • 1
  • Hanno Riess
    • 1
  • Helmut Oettle
    • 1
    • 2
  1. 1.Department for Hematology and OncologyCharité Campus Virchow KlinikumBerlinGermany
  2. 2.Medizin Klinik, mit Schwerpunkt Hämatologie/OnkologieCharité Campus Virchow KlinikumBerlinGermany

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